{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T18:46:54Z","timestamp":1761418014954},"reference-count":21,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2001,4,27]],"date-time":"2001-04-27T00:00:00Z","timestamp":988329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2001,5,15]]},"DOI":"10.1002\/sim.676","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T22:35:38Z","timestamp":1030314938000},"page":"1387-1393","source":"Crossref","is-referenced-by-count":1,"title":["Linking toxicology and epidemiology: the role of mechanistic modelling"],"prefix":"10.1002","volume":"20","author":[{"given":"Christopher J.","family":"Portier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,4,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2307\/3434520"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2307\/3432764"},{"key":"e_1_2_1_4_2","volume-title":"2nd World Congress on Alternatives and Animal Use in the Life Sciences","author":"Kohn M","year":"1997"},{"key":"e_1_2_1_5_2","first-page":"87","article-title":"Receptor\u2010mediated carcinogenesis","volume":"116","author":"Lucier GW","year":"1992","journal-title":"IARC Science Publication"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0004"},{"key":"e_1_2_1_7_2","first-page":"222","article-title":"A biologically\u2010based model for the carcinogenic effects of 2,3,7,8\u2010TCDD in female Sprague\u2010Dawley rats","volume":"29","author":"Portier CJ","year":"1996","journal-title":"Organohalogen Compounds"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0093"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0025-5564(96)00011-9"},{"key":"e_1_2_1_10_2","first-page":"2808","volume-title":"Encyclopedia of Biostatistics","author":"Sherman CD","year":"1998"},{"key":"e_1_2_1_11_2","unstructured":"MelnickR.Introduction to the workshop on characterizing the effects of endocrine disruptors on human health at environmental exposure levels. Environmental Health Perspectives (in press)."},{"key":"e_1_2_1_12_2","article-title":"Quantitative mechanistically based dose response modelling with endocrine active compounds","author":"Andersen M","journal-title":"Environmental Health Perspectives"},{"key":"e_1_2_1_13_2","volume-title":"The Handbook of Environmental Chemistry","author":"Willems B","year":"1999"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1997.8247"},{"key":"e_1_2_1_15_2","first-page":"305","article-title":"Metabolism and anticonvulsant properties of Primidone in the rat","volume":"186","author":"Baumel IP","year":"1973","journal-title":"Journal of Pharm. Exp. Ther."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01059183"},{"issue":"6","key":"e_1_2_1_17_2","first-page":"585","article-title":"Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice","volume":"26","author":"El\u2010Masri HA","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(89)90290-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1999.8715"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1539-6924.1998.tb00366.x"},{"key":"e_1_2_1_21_2","first-page":"508","volume-title":"Assessment of Health Effects from Exposure to Power\u2010Line Frequency Electric and Magnetic Fields","author":"Portier CJ","year":"1998"},{"key":"e_1_2_1_22_2","first-page":"508","volume-title":"NIEHS Report on Health Effects from Exposure to Power\u2010Line Frequency Electric and Magnetic Fields","author":"Portier CJ","year":"1999"}],"container-title":["Statistics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsim.676","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:55:54Z","timestamp":1693418154000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sim.676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,27]]},"references-count":21,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2001,5,15]]}},"alternative-id":["10.1002\/sim.676"],"URL":"https:\/\/doi.org\/10.1002\/sim.676","archive":["Portico"],"relation":{},"ISSN":["0277-6715","1097-0258"],"issn-type":[{"value":"0277-6715","type":"print"},{"value":"1097-0258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,27]]}}}