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We propose an estimator that combines a multistate model with g\u2010computation to estimate the causal effect of treatment delay strategies. In particular, we estimate the impact of strategies such as awaiting natural recovery for 3 months, on the marginal probability of recovery. We use an illness\u2013death model, where illness and death represent, respectively, treatment and recovery. We formulate the causal assumptions needed for identification and the modeling assumptions needed to estimate the quantities of interest. In a simulation study, we present scenarios where the proposed method can make more efficient use of data compared to an alternative approach using cloning\u2013censoring\u2013reweighting. We then showcase the proposed methodology on real data by estimating the effect of treatment delay on a cohort of 1896 couples with unexplained subfertility who seek intrauterine insemination.<\/jats:p>","DOI":"10.1002\/sim.70061","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:12:27Z","timestamp":1744153947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Causal Multistate Models to Evaluate Treatment Delay"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-5643","authenticated-orcid":false,"given":"Ilaria","family":"Prosepe","sequence":"first","affiliation":[{"name":"Department of Biomedical Data Sciences Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2154-4923","authenticated-orcid":false,"given":"Saskia","family":"le Cessie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5395-1422","authenticated-orcid":false,"given":"Hein","family":"Putter","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-9093","authenticated-orcid":false,"given":"Nan","family":"van Geloven","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280208092301"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2712"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10985-008-9097-x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.1.20"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/2530374"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1959.tb00349.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2307\/2528828"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529721"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.810"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780120803"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4385"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2018.304337"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2408-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/09622802231163331"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8471"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/09622802221133551"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k182"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyaa057"},{"key":"e_1_2_8_20_1","volume-title":"Causal Inference","author":"Hern\u00e1n M.","year":"2023"},{"key":"e_1_2_8_21_1","volume-title":"Survival Analysis: Techniques for Censored and Truncated Data","author":"Klein J. 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