{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:11:20Z","timestamp":1764173480034,"version":"3.46.0"},"reference-count":21,"publisher":"Wiley","issue":"18-19","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Missing data are inevitable in clinical trials, and trials that produce categorical ordinal responses are not exempted from this. Typically, missing values in the data occur due to different missing mechanisms, such as missing completely at random, missing at random, and missing not at random. Under a specific missing data regime, when the conditional distribution of the missing data is dependent on the ordinal response variable itself along with other predictor variables, then the missing data mechanism is called\n                    <jats:italic>nonignorable<\/jats:italic>\n                    . In this article, we propose an expectation maximization based algorithm for fitting a proportional odds regression model when the missing responses are nonignorable. We report the results from an extensive simulation study to illustrate the methodology and its finite sample properties. We also apply the proposed method to a recently completed Phase III psoriasis study using an investigational compound. The corresponding SAS program is provided.\n                  <\/jats:p>","DOI":"10.1002\/sim.70114","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T15:44:31Z","timestamp":1755186271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cumulative Logit Ordinal Regression With Proportional Odds Under Nonignorable Missing Responses\u2014Application to Phase III Trial"],"prefix":"10.1002","volume":"44","author":[{"given":"Arnab Kumar","family":"Maity","sequence":"first","affiliation":[{"name":"Boehringer Ingelheim Pharmaceuticals, Inc.  Ridgefield Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaming","family":"Tan","sequence":"additional","affiliation":[{"name":"Pfizer, Inc.  Groton Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-5383","authenticated-orcid":false,"given":"Vivek","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Pfizer, Inc.  Cambridge Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soutir","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Statistics Colorado School of Mines  Golden Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119482260"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1214\/14-BA884"},{"key":"e_1_2_10_5_1","first-page":"482","volume-title":"Categorical Data Analysis","author":"Agresti A.","year":"2003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2019.1608799"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2015.1022644"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-018-1187-4"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533434"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533068"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00031305.2017.1407359"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/rssb.12025"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1982.tb01203.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176346060"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1983.tb01229.x"},{"key":"e_1_2_10_16_1","first-page":"831","article-title":"Parameter Convergence for EM and MM Algorithms","volume":"15","author":"Vaida F.","year":"2005","journal-title":"Statistica Sinica"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214505000000907"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-87987-9_6"},{"key":"e_1_2_10_19_1","first-page":"1","article-title":"On the Consistency of Ordinal Regression Methods","volume":"18","author":"Pedregosa F.","year":"2017","journal-title":"Journal of Machine Learning Research"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14886"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0388-z"}],"container-title":["Statistics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.70114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:06:36Z","timestamp":1764173196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sim.70114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":21,"journal-issue":{"issue":"18-19","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/sim.70114"],"URL":"https:\/\/doi.org\/10.1002\/sim.70114","archive":["Portico"],"relation":{},"ISSN":["0277-6715","1097-0258"],"issn-type":[{"type":"print","value":"0277-6715"},{"type":"electronic","value":"1097-0258"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2024-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70114"}}