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For example, overall and progression\u2010free survival time for different drugs in oncology studies. A common challenge is when an intervention is only effective for some proportion of the population who are not clinically identifiable. Therefore, latent group membership as well as separate survival models for identified groups need to be estimated. However, follow\u2010up in trials may be relatively short leading to substantial censoring. We present a general Bayesian hierarchical framework that can handle this complexity by exploiting the similarity of cure fractions between end\u2010points; accounting for the correlation between them and improving the extrapolation beyond the observed data. Assuming exchangeability between cure fractions facilitates the borrowing of information between end\u2010points. We undertake a comprehensive simulation study to evaluate the model performance under different scenarios. We also show the benefits of using our approach with a motivating example, the CheckMate 067 phase 3 trial consisting of patients with metastatic melanoma treated with first line therapy.<\/jats:p>","DOI":"10.1002\/sim.70132","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T07:29:13Z","timestamp":1748590153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Bayesian Hierarchical Mixture Cure Modelling Framework to Utilize Multiple Survival Datasets for Long\u2010Term Survivorship Estimates: A Case Study From Previously Untreated Metastatic Melanoma"],"prefix":"10.1002","volume":"44","author":[{"given":"Nathan","family":"Green","sequence":"first","affiliation":[{"name":"Department of Statistical Science UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Kurt","sequence":"additional","affiliation":[{"name":"Worldwide Health Economics and Outcomes Research, Bristol Myers Squibb  Lawrence New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriy","family":"Moshyk","sequence":"additional","affiliation":[{"name":"Worldwide Health Economics and Outcomes Research, Bristol Myers Squibb  Lawrence New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Larkin","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Baio","sequence":"additional","affiliation":[{"name":"Department of Statistical Science UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"NICE DSU Technical Support Document No. 14: Survival Analysis for Economic Evaluations Alongside Clinical Trials\u2010Extrapolation With Patient\u2010Level Data","author":"Latimer N.","year":"2013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2366"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2202\/1557\u20104679.1269"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273\u2010019\u201000806\u20104"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00453"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709684"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1910836"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12874\u2010020\u201000997\u2010x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200800222"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3404"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X18788537"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30700\u20109"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.9522"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANNONC.2020.08.1228"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.08.014"},{"issue":"107","key":"e_1_2_10_17_1","first-page":"1","article-title":"Classifying Information\u2010Sharing Methods","volume":"21","author":"Nikolaidis G. 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