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There is concern that MRSA is becoming resistant to other \u201cgold standard\u201d treatments such as vancomycin, and there is disagreement about the relative efficacy of vancomycin compared to linezolid. There are several review papers employing Bayesian Network Meta\u2010Analyses (BNMAs) to investigate which treatments are best for MRSA\u2010related cSSSIs, but none address time\u2010based design inconsistencies. This paper proposes a time\u2010varying BNMA (tBNMA), which models time\u2010varying treatment effects across studies using a Gaussian Process kernel. A dataset is compiled from nine existing MRSA cSSSI NMA review papers containing 58 studies comparing 19 treatments over 19 years. The tBNMA finds evidence of a non\u2010linear trend in the treatment effect of vancomycin\u2013it became less effective than linezolid between 2002 and 2007, but has since recovered statistical equivalence.\n                  <\/jats:p>","DOI":"10.1002\/sim.70160","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T11:34:47Z","timestamp":1752579287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010Varying Bayesian Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"44","author":[{"given":"Patrick M.","family":"LeBlanc","sequence":"first","affiliation":[{"name":"Duke University  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-0710","authenticated-orcid":false,"given":"David","family":"Banks","sequence":"additional","affiliation":[{"name":"Duke University  Durham NC 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