{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:31:28Z","timestamp":1773005488422,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3-5","license":[{"start":{"date-parts":[[2027,2,5]],"date-time":"2027-02-05T00:00:00Z","timestamp":1801785600000},"content-version":"am","delay-in-days":369,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMS\u2010 2515361"],"award-info":[{"award-number":["DMS\u2010 2515361"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Statistics in Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Misclassification Simulation\u2010Extrapolation (MC\u2010SIMEX) is an established method to correct for misclassification in binary covariates in a model. It involves the use of a simulation component which simulates pseudo\u2010datasets with added degree of misclassification in the binary covariate and an extrapolation component which models the covariate's regression coefficients obtained at each level of misclassification using a quadratic function. This quadratic function is then used to extrapolate the covariate's regression coefficients to a point of \u201cno error\u201d in the classification of the binary covariate under question. However, extrapolation functions are not usually known accurately beforehand and are therefore only approximated versions. In this article, we propose an innovative method that uses the exact (not approximated) extrapolation function through the use of a derived relationship between the na\u00efve regression coefficient estimates and the true coefficients in generalized linear models. Simulation studies are conducted to study and compare the numerical properties of the resulting estimator to the original MC\u2010SIMEX estimator. Real data analysis using colon cancer data from the MSKCC cancer registry is also provided.<\/jats:p>","DOI":"10.1002\/sim.70418","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:20:41Z","timestamp":1770283241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Improved Misclassification Simulation Extrapolation (\n                    <scp>MC<\/scp>\n                    \u2010\n                    <scp>SIMEX<\/scp>\n                    ) Algorithm"],"prefix":"10.1002","volume":"45","author":[{"given":"Varadan","family":"Sevilimedu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-3278","authenticated-orcid":false,"given":"Lili","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Environmental Health Sciences, JPH College of Public Health Georgia Southern University  Statesboro Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-4477-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118445112.stat05180"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/86.4.843"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2002.00675.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2005.00396.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1994.10476871"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1995.10476629"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/15598608.2013.772830"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3656"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420010138"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jedm.12090"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/23737484.2022.2106324"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/09622802231168248"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-3242-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2006.12.045"},{"key":"e_1_2_10_17_1","unstructured":"R. J.Carroll F.Lombard H.K\u00fcchenhoff andL. A.Stefanski \u201cAsymptotics for the Simex Estimator in Structural Measurement Error Models \u201d1994."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.2.209"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.03.059"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.7958"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1964.tb00553.x"}],"container-title":["Statistics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.70418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/sim.70418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/sim.70418","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/sim.70418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:06:09Z","timestamp":1772996769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/sim.70418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":20,"journal-issue":{"issue":"3-5","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/sim.70418"],"URL":"https:\/\/doi.org\/10.1002\/sim.70418","archive":["Portico"],"relation":{},"ISSN":["0277-6715","1097-0258"],"issn-type":[{"value":"0277-6715","type":"print"},{"value":"1097-0258","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2024-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70418"}}