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When it comes to adverse effects in clinical trials, these are often most adequately handled using survival methods. A common\u2010effect model that is able to process data in commonly quoted formats in terms of hazard ratios has previously been proposed for this purpose. In order to accommodate potential heterogeneity between studies, we have extended the model by Holzhauer to a random\u2010effects approach. The Bayesian model is described in detail, and applications to realistic data sets are discussed along with sensitivity analyses and Monte Carlo simulations to support the conclusions.<\/jats:p>","DOI":"10.1002\/sim.70508","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:33:36Z","timestamp":1775115216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bayesian Random\u2010Effects Meta\u2010Analysis of Aggregate Data on Clinical Events"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-698X","authenticated-orcid":false,"given":"Christian","family":"R\u00f6ver","sequence":"first","affiliation":[{"name":"Department of Medical Statistics University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2942-8712","authenticated-orcid":false,"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Institute for Medical Biometry and Statistics University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Loos","sequence":"additional","affiliation":[{"name":"Global Biostatistics and Epidemiology Merck KGaA  Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-7441","authenticated-orcid":false,"given":"Tim","family":"Friede","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"DZHK (German Center for Cardiovascular Research), Partner site Lower Saxony  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2528"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pst.1915"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7181"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/biom.12242"},{"key":"e_1_2_11_6_1","volume-title":"Statistical Methods for Meta\u2010Analysis","author":"Hedges L. 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