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We consider a common setting in which a phase I sample is comprised of a large cohort of individuals with outcome (ie, current status) data and a vector of inexpensive covariates. Stored biospecimens for individuals in the phase I sample can be assayed to record the marker of interest for individuals selected in a phase II sub\u2010sample. The design challenge is then to select the phase II sub\u2010sample in order to maximize the precision of the marker effect on the time of interest under a proportional hazards model. This problem has not been examined before for current status data and the role of the assessment time is highlighted. Inference based on likelihood and inverse probability weighted estimating functions are considered, with designs centered on score\u2010based residuals, extreme current status observations, or stratified sampling schemes. Data from a registry of patients with psoriatic arthritis is used in an illustration where we study the risk of diabetes as a comorbidity.<\/jats:p>","DOI":"10.1002\/sim.9666","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T02:35:43Z","timestamp":1674527743000},"page":"1207-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Two\u2010phase designs with current status data"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1162-4348","authenticated-orcid":false,"given":"Fangya","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Statistics and Actuarial Science University of Waterloo  Waterloo Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-4908","authenticated-orcid":false,"given":"Richard J.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science University of Waterloo  Waterloo Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-8621-5"},{"key":"e_1_2_10_3_1","volume-title":"The Statistical Analysis of Interval\u2010Censored Failure Time Data","author":"Sun J","year":"2006"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxp029"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214504000000313"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009652024999"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.423"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00985261"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0714980809990055"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2016.303343"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlpt.2012.07.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00185"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10985-015-9355-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/73.1.1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/86.4.755"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9469.2006.00523.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10985-016-9386-8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2008.00998.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/asw067"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10985-019-09461-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjs.10111"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2010.01505.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5656"},{"key":"e_1_2_10_24_1","article-title":"Optimal designs of two\u2010phase studies","author":"Tao R","journal-title":"J Am Stat Assoc"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6523"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119013563"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/87.1.218"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10985-013-9274-4"},{"key":"e_1_2_10_29_1","volume-title":"Analysis of Incomplete Event History Data","author":"Zhan M.","year":"1999"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1996.10476939"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201100131"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1994.10476818"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-4818-1"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1995.10476493"},{"key":"e_1_2_10_35_1","volume-title":"Statistical Methodologies for Genetic Association Studies with Rare Variants","author":"Derkach A.","year":"2014"},{"key":"e_1_2_10_36_1","unstructured":"TherneauTM.A Package for Survival Analysis in R.2020. 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