{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:55Z","timestamp":1753870195892,"version":"3.41.2"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":940,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1ZIABC011561-07"],"award-info":[{"award-number":["1ZIABC011561-07"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a B-cell proliferative disorder that has been designated as a provisional entity in the 2017 World Health Organization classification for lymphoid neoplasms. While EBVMCU may contain varying numbers of cells with Hodgkin and Reed-Sternberg cells-like morphology, the clinical course is benign and must be distinguished from lymphomas. Patients who develop EBVMCU are commonly immunocompromised, with methotrexate (MTX) as the leading cause. Most previously reported cases of EBVMCU describe mucosal ulcers with very little documentation on skin lesions and its course. Here, we report a case of MTX-associated EBVMCU of the lower leg that underwent spontaneous regression after MTX withdrawal, during which negative conversion of local Epstein-Barr virus activation was confirmed.<\/jats:p>","DOI":"10.1002\/ski2.108","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T14:59:49Z","timestamp":1647529189000},"source":"Crossref","is-referenced-by-count":4,"title":["A Case of Methotrexate-Associated Epstein-Barr Virus-Positive Mucocutaneous Ulcer"],"prefix":"10.1093","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-3232","authenticated-orcid":false,"given":"Keiko","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hamamatsu Medical Center, Hamamatsu , Shizuoka ,","place":["Japan"]},{"name":"Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu , Shizuoka ,","place":["Japan"]},{"name":"Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hamamatsu Medical Center, Hamamatsu , Shizuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0539-5040","authenticated-orcid":false,"given":"Hiroaki","family":"Takatori","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hamamatsu Medical Center, Hamamatsu , Shizuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7005-3138","authenticated-orcid":false,"given":"Keisuke","family":"Nagao","sequence":"additional","affiliation":[{"name":"Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health , Bethesda, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Misawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hamamatsu Medical Center, Hamamatsu , Shizuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2355-4869","authenticated-orcid":false,"given":"Tetsuya","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu , Shizuoka ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"issue":"11","key":"2025010818081529000_ski2108-bib-0001","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1182\/blood.V99.11.3909","article-title":"Lymphomas in rheumatoid arthritis patients treated with methotrexate: a 3-year prospective study in France","volume":"99","author":"Mariette","year":"2002","journal-title":"Blood"},{"issue":"3","key":"2025010818081529000_ski2108-bib-0002","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/PAS.0b013e3181cf8622","article-title":"EBV positive mucocutaneous ulcer--a study of 26 cases associated with various sources of immunosuppression","volume":"34","author":"Dojcinov","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"17","key":"2025010818081529000_ski2108-bib-0003","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2018-01-825570","article-title":"EBV(+) mucocutaneous ulcer: a new entity of WHO 2017","volume":"131","author":"McCormack","year":"2018","journal-title":"Blood"},{"issue":"2","key":"2025010818081529000_ski2108-bib-0004","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/j.clml.2018.10.003","article-title":"Epstein-barr virus-positive mucocutaneous ulcer: case report and review of the first 100 published cases","volume":"19","author":"Sinit","year":"2019","journal-title":"Clin Lymphoma, Myeloma & Leukemia"},{"issue":"2","key":"2025010818081529000_ski2108-bib-0005","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00129039-200106000-00001","article-title":"CD79: a review","volume":"9","author":"Chu","year":"2001","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"5","key":"2025010818081529000_ski2108-bib-0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007748","article-title":"CD8+ T cells retain protective functions despite sustained inhibitory receptor expression during Epstein-Barr virus infection in vivo","volume":"15","author":"Chatterjee","year":"2019","journal-title":"PLoS Pathog"}],"container-title":["Skin Health and 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