{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:33Z","timestamp":1786978413475,"version":"build-2736575974"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":894,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurofibromatosis type 1 (NF1), or von Recklinghausen disease, is an autosomal dominant disease that presents with various symptoms, including caf\u00e9-au-lait spots and neurofibromas. NF1 patients occasionally suffer from renal artery vasculopathy, which impairs renal function, while results of a previous report suggested that male NF1 patients have a low creatinine level in peripheral blood. The assessment of renal function in NF1 patients remains inadequate. In this study, renal function in NF1 was assessed. We recruited 308 patients consisting of 149 NF1 patients (77 males and 72 females) and 159 control patients (102 males and 57 females). Creatinine, blood urea nitrogen and haemoglobin A1c in peripheral blood as well as protein, occult blood and sugar in urine were examined. In addition, the estimated glomerular filtration rate was calculated. The mean age and body mass index did not differ significantly between the NF1 patients and controls for both sexes. For both sexes, i) the mean creatinine value was significantly lower in the NF1 patients than in the controls; ii) the mean blood urea nitrogen value did not differ significantly between the NF1 patients and controls; iii) the mean blood urea nitrogen-to-creatinine ratio was significantly higher in the NF1 patients than in the controls; iv) the mean estimated glomerular filtration rate was significantly higher in the NF1 patients than in the controls; and v) the mean haemoglobin A1c value was significantly lower in the NF1 patients than in the controls. In conclusion, NF1 patients may have improved renal function. The clinical significances should be further examined.<\/jats:p>","DOI":"10.1002\/ski2.119","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T15:28:36Z","timestamp":1651505316000},"source":"Crossref","is-referenced-by-count":2,"title":["Improved Renal Function in Neurofibromatosis Type 1 Patients"],"prefix":"10.1093","volume":"2","author":[{"given":"Ken-ichi","family":"Yasuda","sequence":"first","affiliation":[{"name":"Dermatology, Jikei University School of Medicine , Minato-ku, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-8930","authenticated-orcid":false,"given":"Yoshimasa","family":"Nobeyama","sequence":"additional","affiliation":[{"name":"Dermatology, Jikei University School of Medicine , Minato-ku, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Asahina","sequence":"additional","affiliation":[{"name":"Dermatology, Jikei University School of Medicine , Minato-ku, Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"issue":"5","key":"2025010818065452200_ski2119-bib-0001","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/s1470-2045(09)70033-6","article-title":"Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1","volume":"10","author":"Brems","year":"2009","journal-title":"Lancet Oncol"},{"issue":"6","key":"2025010818065452200_ski2119-bib-0002","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/s0895-7061(00)01303-0","article-title":"Arterial distensibility and ambulatory blood pressure monitoring in young patients with neurofibromatosis type 1","volume":"14","author":"Tedesco","year":"2001","journal-title":"Am J Hypertens"},{"issue":"1","key":"2025010818065452200_ski2119-bib-0003","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783x-19-17","article-title":"Renal artery stenosis due to neurofibromatosis type 1: case report and literature review","volume":"19","author":"Duan","year":"2014","journal-title":"Eur J Med Res"},{"issue":"3","key":"2025010818065452200_ski2119-bib-0004","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s00247-010-1854-9","article-title":"Spectrum of renal findings in pediatric fibromuscular dysplasia and neurofibromatosis type 1","volume":"41","author":"Srinivasan","year":"2011","journal-title":"Pediatr Radiol"},{"key":"2025010818065452200_ski2119-bib-0005","doi-asserted-by":"publisher","first-page":"167","DOI":"10.4103\/0974-2069.58323","article-title":"Renal artery stenosis due to neurofibromatosis","volume":"2","author":"Malav","year":"2009","journal-title":"Ann Pediatr Cardiol"},{"key":"2025010818065452200_ski2119-bib-0006","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1542\/peds.2007-3204","article-title":"Neurofibromatosis type 1 revisited","volume":"123","author":"Williams","year":"2009","journal-title":"Pediatrics"},{"issue":"4","key":"2025010818065452200_ski2119-bib-0007","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1677\/erc-07-0142","article-title":"Pheochromocytoma: an update on genetics and management","volume":"14","author":"Karagiannis","year":"2007","journal-title":"Endocr Relat Cancer"},{"key":"2025010818065452200_ski2119-bib-0008","first-page":"80","article-title":"Neurofibromatosis type 1 and renal artery aneurysms: an uncommon entity of severe hypertension","volume":"53","author":"Triantafyllidi","year":"2012","journal-title":"Hellenic J Cardiol"},{"issue":"5","key":"2025010818065452200_ski2119-bib-0009","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1002\/ajmg.a.35829","article-title":"Persistent hypertension despite successful dilation of a stenotic renal artery in a boy with neurofibromatosis type 1","volume":"161A","author":"Ueda","year":"2013","journal-title":"Am J Med Genet A"},{"issue":"3","key":"2025010818065452200_ski2119-bib-0010","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jvs.2007.03.055","article-title":"Vascular abnormalities in patients with neurofibromatosis syndrome type I: clinical spectrum, management, and results","volume":"46","author":"Oderich","year":"2007","journal-title":"J Vasc Surg"},{"issue":"7","key":"2025010818065452200_ski2119-bib-0011","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/1346-8138.13218","article-title":"Nutritional, muscular and metabolic characteristics in patients with neurofibromatosis type 1","volume":"43","author":"Koga","year":"2016","journal-title":"J Dermatol"},{"key":"2025010818065452200_ski2119-bib-0012","first-page":"575","article-title":"Neurofibromatosis. 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