{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:10:02Z","timestamp":1753870202058,"version":"3.41.2"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":802,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Vitiligo is a skin disease associated with significant psychiatric comorbidities. Affective temperaments represent the inherited foundation of personality and represent the biologically stable part of emotional reactivity. Studies assessing the temperament profile of patients with vitiligo are still scarce.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>This was a cross-sectional study enrolling 34 patients with vitiligo and 34 age and sex-matched healthy controls. Affective temperament profile was investigated using the Temperament Evaluation of Memphis, Paris, and San Diego Auto-questionnaire. Dermatology life quality index was used to evaluate disease impact on patients' quality of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found significant differences with vitiligo patients scoring higher in anxious (11.5 \u00b1 4.76 vs. 9.06 \u00b1 6.22; p = 0.036) and lower in hyperthymic (5.79 \u00b1 3.82 vs. 7.5 \u00b1 3.64; p = 0.027) temperaments. Vitiligo worsening reported by patients was associated with recent psychological stressors in 18 cases (52.9%) and Koebner phenomenon in 20 cases (58.8%). Koebner phenomenon was more frequently associated with the hyperthymic temperament (p = 0.035). Cyclothymic temperament was positively correlated with Dermatology life quality index (rho = 0.417, p = 0.014).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study demonstrated that patients with vitiligo have a distinct premorbid temperament profile. Having low hyperthymic and high anxious temperament traits seem to predispose patients to be less resilient to psychological stressors. A better understanding of the affective traits of vitiligo patients would be vital in personalising and adapting the management of this chronic skin disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/ski2.157","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T06:24:45Z","timestamp":1660371885000},"source":"Crossref","is-referenced-by-count":0,"title":["Patients with Vitiligo Have a Distinct Affective Temperament Profile: A Cross-Sectional Study Using Temperament Evaluation of Memphis, Paris, and San Diego Auto-Questionnaire"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3716-9881","authenticated-orcid":false,"given":"Noureddine","family":"Litaiem","sequence":"first","affiliation":[{"name":"Department of Dermatology, Charles Nicolle Hospital , Tunis ,","place":["Tunisia"]},{"name":"Faculty of Medicine of Tunis, University of Tunis el Manar , Tunis 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