{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T16:07:33Z","timestamp":1785686853995,"version":"3.56.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":697,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This article received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ichthyosis vulgaris is an inherited, non-syndromic form of ichthyosis that presents with skin problems. Making up more than 95% cases of ichthyosis, ichthyosis vulgaris is caused by heterozygous loss-of-function mutation of the filaggrin gene, raising the fragility and permeability of the stratum corneum. It typically presents in infancy as xerosis, skin lesions, keratosis pilaris, palmoplantar hyper linearity, scaly dermatosis, and erythroderma, clearly identifiable by age 5. Although majority of patients have a normal lifespan, possible complications include a vitamin D deficiency and auditory problems due to scaling in the ears, besides a drop in quality of life due to dermatological changes. Urea-based creams with 10% urea, ceramides, and other ceramides are often the first line therapy in ichthyosis vulgaris. There is no known curative treatment for ichthyosis vulgaris, but lifelong treatment can alleviate the symptoms. Urea-based creams are highly therapeutic, whereas ammonium lactate 12% lotion with a physiological lipid-based repair cream can help with scaling and dryness. There is also evidence in favour of propylene glycol solutions. Risankizumab, an anti-interleukin-23 drug, and enhancement of natural moisturizing factors are also two highly promising solutions that require additional research. This review aims to provide updates on the manifestation, evaluation, and treatment of ichthyosis vulgaris.<\/jats:p>","DOI":"10.1002\/ski2.187","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T07:12:48Z","timestamp":1669446768000},"source":"Crossref","is-referenced-by-count":19,"title":["Ichthyosis Vulgaris: An Updated Review"],"prefix":"10.1093","volume":"3","author":[{"given":"Huda","family":"Jaffar","sequence":"first","affiliation":[{"name":"Dow University of Health Sciences , Karachi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zobia","family":"Shakir","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences , Karachi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences , Karachi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman Fatima","family":"Ali","sequence":"additional","affiliation":[{"name":"Dow University of Health Sciences , Karachi ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"issue":"3","key":"2025010818084593900_ski2187-bib-0001","first-page":"225","article-title":"Ichthyoses in everyday practice: management of a rare group of diseases","volume":"18","author":"S\u00fc\u00dfmuth","year":"2020","journal-title":"JDDG J Dtsch Dermatol Ges"},{"issue":"4","key":"2025010818084593900_ski2187-bib-0002","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"Palmer","year":"2006","journal-title":"Nat Genet"},{"issue":"5","key":"2025010818084593900_ski2187-bib-0003","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15588","article-title":"Targeted next-generation sequencing identifies nine novel filaggrin gene variants in Chinese Han patients with ichthyosis vulgaris","volume":"177","author":"Chen","year":"2017","journal-title":"Br J Dermatol"},{"key":"2025010818084593900_ski2187-bib-0004","volume-title":"Hereditary and acquired ichthyosis vulgaris","author":"Majmundar","year":"2022"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0005","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/ng1743","article-title":"Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris","volume":"38","author":"Smith","year":"2006","journal-title":"Nat Genet"},{"issue":"5","key":"2025010818084593900_ski2187-bib-0006","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050489","article-title":"3D-organotypic cultures to unravel molecular and cellular abnormalities in atopic dermatitis and ichthyosis vulgaris","volume":"8","author":"Leman","year":"2019","journal-title":"Cells"},{"issue":"9","key":"2025010818084593900_ski2187-bib-0007","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjx183\/4161883","article-title":"Surgical management of digital ischemia caused by constriction band formation in a patient with ichthyosis vulgaris","volume":"2017","author":"Ran Zhu","year":"2017","journal-title":"J Surg Case Rep"},{"issue":"2","key":"2025010818084593900_ski2187-bib-0008","doi-asserted-by":"publisher","first-page":"214","DOI":"10.11613\/bm.2019.020501","article-title":"Filaggrin and atopic march","volume":"29","author":"\u010cepelak","year":"2019","journal-title":"Biochem Medica"},{"issue":"2","key":"2025010818084593900_ski2187-bib-0009","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.adengl.2014.12.007","article-title":"The role of filaggrin in the skin barrier and disease development","volume":"106","author":"Armengot-Carbo","year":"2015","journal-title":"Actas Dermosifiliogr"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0010","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/j.1365-2133.2009.09582.x","article-title":"FLG mutations in ichthyosis vulgaris and atopic eczema: spectrum of mutations and population genetics","volume":"162","author":"Akiyama","year":"2010","journal-title":"Br J Dermatol"},{"issue":"1","key":"2025010818084593900_ski2187-bib-0011","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/j.1365-2133.2011.10331.x","article-title":"Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations","volume":"165","author":"Chen","year":"2011","journal-title":"Br J Dermatol"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0012","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1398-9995.2010.02493.x","article-title":"Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis","volume":"66","author":"Zhang","year":"2011","journal-title":"Allergy"},{"issue":"2","key":"2025010818084593900_ski2187-bib-0013","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1468-3083.2011.04435.x","article-title":"Mutations analysis in filaggrin gene in northern China patients with atopic dermatitis","volume":"27","author":"Li","year":"2013","journal-title":"J Eur Acad Dermatol Venereol JEADV"},{"issue":"2","key":"2025010818084593900_ski2187-bib-0014","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/j.1365-2133.2009.09112.x","article-title":"Analysis of Taiwanese ichthyosis vulgaris families further demonstrates differences in FLG mutations between European and Asian populations","volume":"161","author":"Hsu","year":"2009","journal-title":"Br J Dermatol"},{"issue":"6","key":"2025010818084593900_ski2187-bib-0015","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1038\/sj.jid.5701205","article-title":"Specific filaggrin mutations cause ichthyosis vulgaris and are significantly associated with atopic dermatitis in Japan","volume":"128","author":"Nomura","year":"2008","journal-title":"J Invest Dermatol"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0016","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.jaci.2011.01.031","article-title":"Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy","volume":"127","author":"Brown","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"2025010818084593900_ski2187-bib-0017","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1111\/bjd.12219","article-title":"Ichthyosis vulgaris: the filaggrin mutation disease","volume":"168","author":"Thyssen","year":"2013","journal-title":"Br J Dermatol"},{"issue":"6","key":"2025010818084593900_ski2187-bib-0018","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1007\/s00431-018-3152-8","article-title":"Eyelash length for the diagnosis of atopic dermatitis and ichthyosis vulgaris in children\u2014a case control study","volume":"177","author":"Singh","year":"2018","journal-title":"Eur J Pediatr"},{"issue":"12","key":"2025010818084593900_ski2187-bib-0019","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1111\/ijd.14213","article-title":"Filaggrin gene polymorphisms in Iranian ichthyosis vulgaris and atopic dermatitis patients","volume":"57","author":"Hassani","year":"2018","journal-title":"Int J Dermatol"},{"issue":"3 Pt 2","key":"2025010818084593900_ski2187-bib-0020","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/jid.2011.393","article-title":"One remarkable molecule: filaggrin","volume":"132","author":"Brown","year":"2012","journal-title":"J Invest Dermatol"},{"issue":"Pt 9","key":"2025010818084593900_ski2187-bib-0021","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: role in skin barrier function and disease","volume":"122","author":"Sandilands","year":"2009","journal-title":"J Cell Sci"},{"issue":"12","key":"2025010818084593900_ski2187-bib-0022","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1111\/j.1398-9995.2009.02080.x","article-title":"Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure","volume":"64","author":"Schuttelaar","year":"2009","journal-title":"Allergy"},{"issue":"Suppl 1","key":"2025010818084593900_ski2187-bib-0023","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1396-0296.2004.04s1005.x","article-title":"Moisturization and skin barrier function","volume":"17","author":"Rawlings","year":"2004","journal-title":"Dermatol Ther"},{"issue":"4","key":"2025010818084593900_ski2187-bib-0024","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jaci.2008.08.002","article-title":"Filaggrin in atopic dermatitis","volume":"122","author":"O\u2019Regan","year":"2008","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"2025010818084593900_ski2187-bib-0025","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1016\/j.ajpath.2011.01.053","article-title":"Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function","volume":"178","author":"Gruber","year":"2011","journal-title":"Am J Pathol"},{"issue":"7","key":"2025010818084593900_ski2187-bib-0026","doi-asserted-by":"publisher","first-page":"4097","DOI":"10.1073\/pnas.78.7.4097","article-title":"Characterization of a class of cationic proteins that specifically interact with intermediate filaments","volume":"78","author":"Steinert","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2025010818084593900_ski2187-bib-0027","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2332\/allergolint.10-rai-0270","article-title":"Filaggrin gene defects and the risk of developing allergic disorders","volume":"60","author":"Osawa","year":"2011","journal-title":"Allergol Int Off J Jpn Soc Allergol"},{"issue":"6","key":"2025010818084593900_ski2187-bib-0028","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/j.jaci.2010.09.015","article-title":"Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus","volume":"126","author":"Miajlovic","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"2025010818084593900_ski2187-bib-0029","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1177\/026119291103900508","article-title":"Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down","volume":"39","author":"K\u00fcchler","year":"2011","journal-title":"Altern Lab Anim ATLA"},{"issue":"2","key":"2025010818084593900_ski2187-bib-0030","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/jid.2008.252","article-title":"Evolving concepts of pathogenesis in atopic dermatitis and other eczemas","volume":"129","author":"Hanifin","year":"2009","journal-title":"J Invest Dermatol"},{"issue":"12","key":"2025010818084593900_ski2187-bib-0031","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028254","article-title":"Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris","volume":"6","author":"Winge","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"2025010818084593900_ski2187-bib-0032","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000163083","article-title":"Filaggrin mutation c.3321delA in a Korean patient with ichthyosis vulgaris and atopic dermatitis","volume":"218","author":"Kang","year":"2009","journal-title":"Dermatol Basel Switz"},{"issue":"2","key":"2025010818084593900_ski2187-bib-0033","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1365-2230.2011.04229.x","article-title":"Novel FLG mutations associated with ichthyosis vulgaris in the Chinese population","volume":"37","author":"Xiong","year":"2012","journal-title":"Clin Exp Dermatol"},{"issue":"5","key":"2025010818084593900_ski2187-bib-0034","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098235","article-title":"Filaggrin gene mutation c.3321delA is associated with various clinical features of atopic dermatitis in the Chinese Han population","volume":"9","author":"Meng","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"2025010818084593900_ski2187-bib-0035","doi-asserted-by":"publisher","DOI":"10.1515\/dmpt-2019-0008","article-title":"X-linked and autosomal dominant forms of the ichthyosis in coinheritance","volume":"34","author":"Alaverdian","year":"2019","journal-title":"Drug Metab Pers Ther"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0036","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/1523-1747.ep12264813","article-title":"Ichthyosis vulgaris: identification of a defect in synthesis of filaggrin correlated with an absence of keratohyaline granules","volume":"84","author":"Sybert","year":"1985","journal-title":"J Invest Dermatol"},{"key":"2025010818084593900_ski2187-bib-0037","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.yadr.2007.07.011","article-title":"Ichthyosis update: towards a function-driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders","volume":"23","author":"Schmuth","year":"2007","journal-title":"Adv Dermatol"},{"issue":"1","key":"2025010818084593900_ski2187-bib-0038","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00670-2","article-title":"TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents","volume":"7","author":"Wallmeyer","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0039","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/jid.2013.402","article-title":"Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct","volume":"134","author":"V\u00e1vrov\u00e1","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"5","key":"2025010818084593900_ski2187-bib-0040","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1111\/cge.13704","article-title":"Next-generation sequencing through multi-gene panel testing for diagnosis of hereditary ichthyosis in Chinese","volume":"97","author":"Cheng","year":"2020","journal-title":"Clin Genet"},{"issue":"10","key":"2025010818084593900_ski2187-bib-0041","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075355","article-title":"Distinguishing ichthyoses by protein profiling","volume":"8","author":"Rice","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"2025010818084593900_ski2187-bib-0042","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1111\/1523-1747.ep12470251","article-title":"Keratinocytes cultured from subjects with ichthyosis vulgaris are phenotypically abnormal","volume":"88","author":"Fleckman","year":"1987","journal-title":"J Invest Dermatol"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0043","doi-asserted-by":"publisher","DOI":"10.3390\/genes12030373","article-title":"Novel homozygous mutations in the genes TGM1, SULT2B1, SPINK5 and FLG in four families underlying congenital ichthyosis","volume":"12","author":"Fozia","year":"2021","journal-title":"Genes"},{"key":"2025010818084593900_ski2187-bib-0044","volume-title":"Ichthyosis Vulgaris - Causes, Symptoms, Complications & Treatment","year":"2018"},{"issue":"6","key":"2025010818084593900_ski2187-bib-0045","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2165\/11311070-000000000-00000","article-title":"Ichthyosis: clinical manifestations and practical treatment options","volume":"10","author":"Oji","year":"2009","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"2025010818084593900_ski2187-bib-0046","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/j.1365-2133.2008.08999.x","article-title":"Ichthyosis vulgaris: novel FLG mutations in the German population and high presence of CD1a+ cells in the epidermis of the atopic subgroup","volume":"160","author":"Oji","year":"2009","journal-title":"Br J Dermatol"},{"issue":"1","key":"2025010818084593900_ski2187-bib-0047","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.sjopt.2015.12.004","article-title":"Ocular manifestation of Ichthyosis","volume":"30","author":"Al-Amry","year":"2016","journal-title":"Saudi J Ophthalmol"},{"issue":"1","key":"2025010818084593900_ski2187-bib-0048","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/ddg.13968","article-title":"Spectrum of ichthyoses in an Austrian ichthyosis cohort from 2004 to 2017","volume":"18","author":"Seidl-Philipp","year":"2020","journal-title":"J Dtsch Dermatol Ges J Ger Soc Dermatol JDDG"},{"issue":"3 Pt 2","key":"2025010818084593900_ski2187-bib-0049","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/jid.2011.435","article-title":"Skin barrier disruption: a requirement for allergen sensitization?","volume":"132","author":"De Benedetto","year":"2012","journal-title":"J Invest Dermatol"},{"issue":"1","key":"2025010818084593900_ski2187-bib-0050","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/ced.14406","article-title":"Disseminated tinea incognita in a patient with ichthyosis vulgaris and eczema","volume":"46","author":"Steele","year":"2021","journal-title":"Clin Exp Dermatol"},{"issue":"6","key":"2025010818084593900_ski2187-bib-0051","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/bjd.19835","article-title":"Coexistence of palmoplantar pustulosis and ichthyosis vulgaris treated by risankizumab","volume":"184","author":"Hugo","year":"2021","journal-title":"Br J Dermatol"},{"issue":"1","key":"2025010818084593900_ski2187-bib-0052","doi-asserted-by":"publisher","first-page":"261","DOI":"10.4103\/jfmpc.jfmpc_141_17","article-title":"A rare case of acute intermittent porphyria with ichthyosis vulgaris in a young boy","volume":"7","author":"Varshney","year":"2018","journal-title":"J Fam Med Prim Care"},{"key":"2025010818084593900_ski2187-bib-0053","volume-title":"VisualDx - Eczema craquel\u00e9","author":"Craft"},{"key":"2025010818084593900_ski2187-bib-0054","volume-title":"VisualDx - Ichthyosis vulgaris","author":"Li"},{"issue":"1","key":"2025010818084593900_ski2187-bib-0055","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1529-8019.2012.01517.x","article-title":"Complications of ichthyosis beyond the skin: non-cutaneous complications of ichthyosis","volume":"26","author":"Diaz","year":"2013","journal-title":"Dermatol Ther"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0056","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/pde.12292","article-title":"Frequency of ear symptoms and hearing loss in ichthyosis: a pilot survey study","volume":"31","author":"Huang","year":"2014","journal-title":"Pediatr Dermatol"},{"issue":"8","key":"2025010818084593900_ski2187-bib-0057","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1097\/mph.0000000000000953","article-title":"Cutaneous melanoma in association with ichthyosis vulgaris","volume":"39","author":"Tas","year":"2017","journal-title":"J Pediatr Hematol Oncol"},{"key":"2025010818084593900_ski2187-bib-0058","journal-title":"Ichthyosis vulgaris: diagnosis and treatment"},{"issue":"6","key":"2025010818084593900_ski2187-bib-0059","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12690","article-title":"Topical urea in skincare: a review","volume":"31","author":"Celleno","year":"2018","journal-title":"Dermatol Ther"},{"issue":"6","key":"2025010818084593900_ski2187-bib-0060","doi-asserted-by":"publisher","DOI":"10.23736\/s0392-0488.17.05743-1","article-title":"Treatment of ichthyosis vulgaris with a urea-based emulsion: videodermatoscopy and confocal microscopy evaluation","volume":"152","author":"Benintende","year":"2017","journal-title":"G Ital Dermatol venereol Organo Uff Soc Ital Dermatol Sifilogr"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0061","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1365-2133.1972.tb02231.x","article-title":"Out-patient treatment of ichthyosis: a double-blind trial of ointments","volume":"86","author":"Pope","year":"1972","journal-title":"Br J Dermatol"},{"issue":"7","key":"2025010818084593900_ski2187-bib-0062","first-page":"5","article-title":"Overcoming the barrier treatment of ichthyosis","volume":"3","author":"Bellew","year":"2010","journal-title":"J Clin Aesthetic Dermatol"},{"issue":"4","key":"2025010818084593900_ski2187-bib-0063","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1001\/jama.1972.03200040091019","article-title":"Propylene glycol with occlusion for treatment of ichthyosis","volume":"220","author":"Goldsmith","year":"1972","journal-title":"JAMA, J Am Med Assoc"},{"issue":"3","key":"2025010818084593900_ski2187-bib-0064","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9030237","article-title":"Trifarotene: a current review and perspectives in dermatology","volume":"9","author":"Cosio","year":"2021","journal-title":"Biomedicines"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ski2.187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ski2.187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/3\/1\/ski2.187\/59935051\/skinhd_3_1_e187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/3\/1\/ski2.187\/59935051\/skinhd_3_1_e187.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T18:08:58Z","timestamp":1736359738000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/doi\/10.1002\/ski2.187\/7755530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ski2.187","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2]]},"published":{"date-parts":[[2022,11,25]]},"article-number":"ski2.187"}}