{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:04:18Z","timestamp":1787069058188,"version":"build-2736575974"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":596,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Wells syndrome, also referred to as eosinophilic cellulitis, is a rare and often sporadic inflammatory skin condition whose aetiology remains uncertain. Clinically, this condition presents as a collection of erythematous, oedematous, and tender skin lesions most often affecting the extremities and trunk that can mimic cellulitis. Histologically, Wells syndrome is characterised by inflammatory changes and eosinophilic infiltration of the dermis with the absence of underlying infection, thereby distinguishing it from cellulitis. Due to the rarity of this syndrome and its ambiguous presentation, there remains to be a definitive strategy for treatment. Recent case reports have documented varying success and recurrence with the use of oral and topical corticosteroids, antifungals, antibiotics, immunosuppressants and antihistamines. Here, we report a unique case of progressively worsening neutrophilic-rich Wells syndrome on the vertex of the scalp that was successfully treated with a combination of dupilumab and oral corticosteroids.<\/jats:p>","DOI":"10.1002\/ski2.206","type":"journal-article","created":{"date-parts":[[2023,2,25]],"date-time":"2023-02-25T01:40:30Z","timestamp":1677289230000},"source":"Crossref","is-referenced-by-count":8,"title":["Atypical Wells Syndrome Successfully Treated with Dupilumab"],"prefix":"10.1093","volume":"3","author":[{"given":"Patrick","family":"McMullan","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Connecticut Health Center , Farmington, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Torre","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Connecticut Health Center , Farmington, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueheidi","family":"Santiago","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Connecticut Health Center , Farmington, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Weston","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Connecticut Health Center , Farmington, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Connecticut Health Center , Farmington, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"issue":"9","key":"2025010818141128800_ski2206-bib-0001","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1111\/jdv.13706","article-title":"Treatment of eosinophilic cellulitis (Wells syndrome) \u2013 a systematic review","volume":"30","author":"R\u00e4\u00dfler","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"9","key":"2025010818141128800_ski2206-bib-0002","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1001\/archderm.142.9.1157","article-title":"Wells syndrome in adults and children: a report of 19 cases","volume":"142","author":"Caputo","year":"2006","journal-title":"Arch Dermatol"},{"issue":"4","key":"2025010818141128800_ski2206-bib-0003","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3315\/jdcr.2013.1157","article-title":"Wells syndrome (eosinophilic cellulitis): proposed diagnostic criteria and a literature review of the drug-induced variant","volume":"7","author":"Heelan","year":"2013","journal-title":"J Dermatol Case Rep"},{"issue":"2","key":"2025010818141128800_ski2206-bib-0004","doi-asserted-by":"publisher","first-page":"91","DOI":"10.4172\/plastic-surgery.1000741","article-title":"Diagnosis and management of eosinophilic cellulitis (Wells\u2019 syndrome): a case series and literature review","volume":"20","author":"Sinno","year":"2012","journal-title":"Can J Plast Surg"},{"issue":"2","key":"2025010818141128800_ski2206-bib-0005","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.jaci.2021.03.024","article-title":"Rethinking neutrophils and eosinophils in chronic rhinosinusitis","volume":"148","author":"Delemarre","year":"2021","journal-title":"J Allergy Clin Immunol"},{"issue":"11","key":"2025010818141128800_ski2206-bib-0006","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1111\/ddg.14598","article-title":"Dupilumab in eosinophilic cellulitis (Wells\u2019 syndrome) \u2013 case report of a potential new treatment option","volume":"19","author":"Traidl","year":"2021","journal-title":"JDDG J. 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