{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:10:14Z","timestamp":1753870214612,"version":"3.41.2"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":632,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This article received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cutaneous hypersensitivity eruptions in chronic lymphocytic leukemia (CLL)\/small lymphocytic lymphoma (SLL) are a clinically and histologically heterogeneous group that can either precede, occur with, or follow the development of a hematologic malignancy. Therefore, establishing the diagnosis requires careful clinical and pathologic correlation and an understanding of the broad spectrum of presentations. Data is lacking on the correlation of skin disease with molecular\/cytogenetic risk profiling of the tumor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aims of this study were to characterize the clinical, histological, and genetic aberrations in recurrent cutaneous hypersensitivity reactions in patients with CLL\/SLL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A single site academic retrospective chart review of medical records, histopathology, molecular and cytogenetic data in CLL\/SLL patients who developed biopsy-proven cutaneous hypersensitivity reactions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Five hundred one new diagnoses of CLL\/SLL with 73 patients requiring cutaneous biopsies for skin lesions or rashes were identified. With exclusion criteria, 20 biopsies were identified from 17 patients (mean age, 69.6 years, females = 9) with unexplained cutaneous eruptions. These were commonly pruritic, erythematous papules above the waist. Most biopsies had a prominent superficial, deep dermal eosinophilic infiltrate (85%), with a robust T-cell predominant dermal infiltrate in 40%. Five out of 17 patients (29%) had a predominately folliculocentric CD4+ T-cell infiltrate; all occurring on the head and neck. Overall, the prevalence of cutaneous hypersensitivity eruptions requiring biopsy was 3.4% (n = 17), and the prevalence of folliculocentric CD4+ T-cell infiltrate was 1% (n = 5).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Cutaneous hypersensitivity reactions in CLL\/SLL are heterogeneous; however, folliculotropic CD4+ T-cell infiltrates may be seen in a small but distinct clinical subset of patients. Commonly tested cytogenetic aberrations in CLL\/SLL do not appear to be correlated with the presence of cutaneous hypersensitivity reactions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/ski2.208","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T10:47:02Z","timestamp":1674125222000},"source":"Crossref","is-referenced-by-count":1,"title":["Folliculocentric Lymphocytic Hypersensitivity Reactions in CLL\/SLL Patients: A Unique Clinicopathologic Entity Amongst Non-Specific Hypersensitivity Reactions"],"prefix":"10.1093","volume":"3","author":[{"given":"James","family":"Abbott","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Corean","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley M.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, Utah ,","place":["USA"]},{"name":"Department of Population Health Sciences, University of Utah , Salt Lake City, Utah ,","place":["USA"]},{"name":"Huntsman Cancer Institute , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R.","family":"Florell","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney","family":"Miles","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Utah , Salt Lake City, Utah ,","place":["USA"]},{"name":"Huntsman Cancer Institute , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Stephens","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute , Salt Lake City, Utah ,","place":["USA"]},{"name":"Department of Hematology and Hematologic Malignancies, University of Utah , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Utah , Salt Lake City, Utah ,","place":["USA"]},{"name":"Huntsman Cancer Institute , Salt Lake City, Utah ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"author":"Surveillance, Epidemiology, and End Results (SEER) Program (","key":"2025010818144794000_ski2208-bib-0001"},{"issue":"3","key":"2025010818144794000_ski2208-bib-0002","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/cup.13389","article-title":"Eosinophilic dermatosis of hematologic malignancy: correlation of molecular characteristics of skin lesions and extracutaneous manifestations of hematologic malignancy","volume":"46","author":"Meiss","year":"2019","journal-title":"J Cutan Pathol"},{"issue":"7","key":"2025010818144794000_ski2208-bib-0003","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/j.1600-0560.2012.01906.x","article-title":"Eosinophilic dermatosis of hematologic malignancy","volume":"39","author":"Farber","year":"2012","journal-title":"J Cutan Pathol"},{"issue":"3","key":"2025010818144794000_ski2208-bib-0004","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1182\/blood.V26.3.257.257","article-title":"Exaggerated delayed hypersensitivity to mosquito bites in chronic lymphocytic leukemia","volume":"26","author":"Weed","year":"1965","journal-title":"Blood"},{"issue":"12","key":"2025010818144794000_ski2208-bib-0005","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1001\/archderm.135.12.1503","article-title":"Insect bite-like reaction in patients with hematologic malignant neoplasms","volume":"135","author":"Barzilai","year":"1999","journal-title":"Arch Dermatol"},{"issue":"10","key":"2025010818144794000_ski2208-bib-0006","first-page":"1378","article-title":"Eosinophilic dermatosis of myeloproliferative disease: characterization of a unique eruption in patients with hematologic disorders","volume":"137","author":"Byrd","year":"2001","journal-title":"Arch Dermatol"},{"issue":"9","key":"2025010818144794000_ski2208-bib-0007","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1111\/jdv.14805","article-title":"T-cell papulosis associated with B-cell malignancy: a distinctive clinicopathologic entity","volume":"32","author":"Visseaux","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"2025010818144794000_ski2208-bib-0008","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0190-9622(98)70398-6","article-title":"Exaggerated arthropod-bite lesions in patients with chronic lymphocytic leukemia: a clinical, histopathologic, and immunopathologic study of eight patients","volume":"39","author":"Davis","year":"1998","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"2025010818144794000_ski2208-bib-0009","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1111\/j.1365-2133.2012.10966.x","article-title":"Insect bite-like reactions in a patient with B-cell chronic lymphocytic leukaemia: fluorescence in situ hybridization analysis revealed neoplastic B cells within the skin infiltrate","volume":"167","author":"Mitteldorf","year":"2012","journal-title":"Br J Dermatol"},{"issue":"1","key":"2025010818144794000_ski2208-bib-0010","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/jdv.12454","article-title":"Folliculotropic T-cell infiltrates associated with B-cell chronic lymphocytic leukaemia or MALT lymphoma may reveal either true mycosis fungoides or pseudolymphomatous reaction: seven cases and review of the literature","volume":"29","author":"Ingen-Housz-Oro","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"2025010818144794000_ski2208-bib-0011","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1182\/asheducation-2017.1.329","article-title":"The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatment","volume":"2017","author":"Gaidano","year":"2017","journal-title":"Hematology"},{"issue":"8","key":"2025010818144794000_ski2208-bib-0012","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1182\/blood-2012-09-458265","article-title":"Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia","volume":"121","author":"Rossi","year":"2013","journal-title":"Blood"},{"issue":"9","key":"2025010818144794000_ski2208-bib-0013","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/s0145-2126(99)00088-0","article-title":"The prognostic significance of 13q14 deletions in chronic lymphocytic leukemia","volume":"23","author":"Starostik","year":"1999","journal-title":"Leuk Res"},{"issue":"3","key":"2025010818144794000_ski2208-bib-0014","doi-asserted-by":"publisher","first-page":"572","DOI":"10.4103\/ijc.IJC_291_17","article-title":"Prevalence of cytogenetic abnormalities in chronic lymphocytic leukemia in the southern part of Turkey","volume":"54","author":"Bagir","year":"2017","journal-title":"Indian J Cancer"},{"issue":"26","key":"2025010818144794000_ski2208-bib-0015","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1056\/NEJM200012283432602","article-title":"Genomic aberrations and survival in chronic lymphocytic leukemia","volume":"343","author":"D\u00f6hner","year":"2000","journal-title":"N Engl J Med"},{"issue":"8","key":"2025010818144794000_ski2208-bib-0016","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1097\/00000478-199608000-00009","article-title":"Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia: a clinicopathologic and prognostic study of 42 patients","volume":"20","author":"Lorenzo","year":"1996","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"2025010818144794000_ski2208-bib-0017","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/ejh.12015","article-title":"Insect-bite-like reaction in patients with chronic lymphocytic leukemia: a study from the Israeli Chronic Lymphocytic Leukemia Study Group","volume":"89","author":"Bairey","year":"2012","journal-title":"Eur J Haematol"},{"issue":"1","key":"2025010818144794000_ski2208-bib-0018","first-page":"81","article-title":"Hypersensitive reactions to mosquito bites in congenital agammaglobulinemia","volume":"56","author":"Shibasaki","year":"1986","journal-title":"Ann Allergy"},{"issue":"1","key":"2025010818144794000_ski2208-bib-0019","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4103\/0378-6323.148612","article-title":"Insect bite reaction and HIV infection","volume":"81","author":"Nair","year":"2015","journal-title":"Indian J Dermatol Venereol Leprol"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ski2.208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ski2.208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/3\/3\/ski2.208\/59729514\/skinhd_3_3_e208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/3\/3\/ski2.208\/59729514\/skinhd_3_3_e208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T18:14:56Z","timestamp":1736360096000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/doi\/10.1002\/ski2.208\/7755668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ski2.208","relation":{},"ISSN":["2690-442X"],"issn-type":[{"type":"electronic","value":"2690-442X"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2023,1,19]]},"article-number":"ski2.208"}}