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We present the case of an 11-year-old girl presenting to dermatology with an acneiform facial rash and associated bacterial lymphadenitis. History was significant for otitis media, primary tooth retention, low impact wrist fracture, infantile acne and an absence of eczema or pneumonia. Investigations demonstrated mildly elevated IgE, normal eosinophils but positivity for a STAT3 gene mutation\u2014thus representing a case of HIES presenting as an acneiform facial rash with absence of other primary immunological features.<\/jats:p>","DOI":"10.1002\/ski2.297","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:35:42Z","timestamp":1696487742000},"source":"Crossref","is-referenced-by-count":0,"title":["Hyper-IgE Syndrome in an 11 Year Old Female Presenting with Acneiform Rash"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4834-6225","authenticated-orcid":false,"given":"Berbie","family":"Byrne","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Hospital Galway , Galway ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Hefferon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University 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