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It is rare but can cause chronic and intractable symptoms which can impede the quality of life of those affected. Treatment options are variable and not enough data exists to provide a definitive protocol for management. We present this case to highlight a simple, efficacious way for dermatologists to treat the condition and provide a literature review.<\/jats:p>","DOI":"10.1002\/ski2.325","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T02:06:45Z","timestamp":1703729205000},"source":"Crossref","is-referenced-by-count":1,"title":["Epidermolytic Hyperkeratosis of the Vulva: Case Report and Review of the Literature"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0878-6664","authenticated-orcid":false,"given":"Dilshad","family":"Sachedina","sequence":"first","affiliation":[{"name":"Department of Dermatology, Boston Medical Center , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Villa-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Boston Medical Center , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candice","family":"Brem","sequence":"additional","affiliation":[{"name":"Section of Dermatopathology, Department of Dermatology, Boston University Chobanian & Avedisian School of Medicine , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debjani","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Boston Medical Center , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"issue":"5","key":"2026012701370529600_ski2325-bib-0001","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1111\/ced.13395","article-title":"Asymptomatic hyperkeratotic plaque on the vulva of a patient with lichen sclerosus","volume":"43","author":"Iglesias-Plaza","year":"2018","journal-title":"Clin Exp Dermatol"},{"issue":"4","key":"2026012701370529600_ski2325-bib-0002","first-page":"33","article-title":"Localized epidermolytic hyperkeratosis of the female genitalia: a case report and review of an underappreciated disorder of women","volume":"7","author":"High","year":"2005","journal-title":"MedGenMed"},{"issue":"1","key":"2026012701370529600_ski2325-bib-0003","doi-asserted-by":"publisher","DOI":"10.5070\/d3271052038","article-title":"Epidermolytic hyperkeratosis of the vulva","volume":"27","author":"Dai","year":"2021","journal-title":"Dermatol Online J"},{"issue":"5","key":"2026012701370529600_ski2325-bib-0004","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1365-2230.2004.01581.x","article-title":"Multiple scrotal epidermolytic acanthomas; 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