{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:16:18Z","timestamp":1780708578733,"version":"3.54.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":141,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-191-112"],"award-info":[{"award-number":["R-154-000-191-112"]}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-404-112"],"award-info":[{"award-number":["R-154-000-404-112"]}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-553-112"],"award-info":[{"award-number":["R-154-000-553-112"]}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-565-112"],"award-info":[{"award-number":["R-154-000-565-112"]}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-630-112"],"award-info":[{"award-number":["R-154-000-630-112"]}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-A08-592"],"award-info":[{"award-number":["R-154-000-A08-592"]}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-A27-597"],"award-info":[{"award-number":["R-154-000-A27-597"]}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-A91-592"],"award-info":[{"award-number":["R-154-000-A91-592"]}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-A95-592"],"award-info":[{"award-number":["R-154-000-A95-592"]}]},{"name":"Singapore Ministry of Education Academic Research Fund","award":["R-154-000-B99-114"],"award-info":[{"award-number":["R-154-000-B99-114"]}]},{"DOI":"10.13039\/501100023996","name":"Singapore Food Agency","doi-asserted-by":"publisher","award":["SFS_RND_SUFP_001_04"],"award-info":[{"award-number":["SFS_RND_SUFP_001_04"]}],"id":[{"id":"10.13039\/501100023996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023996","name":"Singapore Food Agency","doi-asserted-by":"publisher","award":["W22W3D0006"],"award-info":[{"award-number":["W22W3D0006"]}],"id":[{"id":"10.13039\/501100023996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council (NMRC)","doi-asserted-by":"publisher","award":["NMRC\/1150\/2008"],"award-info":[{"award-number":["NMRC\/1150\/2008"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council (NMRC)","doi-asserted-by":"publisher","award":["OFIRG20nov-0033"],"award-info":[{"award-number":["OFIRG20nov-0033"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science Technology and Research (A*STAR)","doi-asserted-by":"crossref","award":["APG2013\/108"],"award-info":[{"award-number":["APG2013\/108"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science Technology and Research (A*STAR)","doi-asserted-by":"crossref","award":["H17\/01\/a0\/008"],"award-info":[{"award-number":["H17\/01\/a0\/008"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation (NRF)","doi-asserted-by":"publisher","award":["NRF-MP-2020-0004"],"award-info":[{"award-number":["NRF-MP-2020-0004"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022896","name":"Singapore Immunology Network","doi-asserted-by":"crossref","award":["SIgN-06-006"],"award-info":[{"award-number":["SIgN-06-006"]}],"id":[{"id":"10.13039\/100022896","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100022896","name":"Singapore Immunology Network","doi-asserted-by":"crossref","award":["SIgN-08-020"],"award-info":[{"award-number":["SIgN-08-020"]}],"id":[{"id":"10.13039\/100022896","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012415","name":"Biomedical Research Council (BMRC)","doi-asserted-by":"publisher","award":["BMRC\/01\/1\/21\/18\/077"],"award-info":[{"award-number":["BMRC\/01\/1\/21\/18\/077"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012415","name":"Biomedical Research Council (BMRC)","doi-asserted-by":"publisher","award":["BMRC\/04\/1\/21\/19\/315"],"award-info":[{"award-number":["BMRC\/04\/1\/21\/19\/315"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012415","name":"Biomedical Research Council (BMRC)","doi-asserted-by":"publisher","award":["BMRC\/APG2013\/108"],"award-info":[{"award-number":["BMRC\/APG2013\/108"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001352","name":"National University of Singapore, Singapore","doi-asserted-by":"publisher","award":["N-154-000-038-001"],"award-info":[{"award-number":["N-154-000-038-001"]}],"id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Objective<\/jats:title>\n                    <jats:p>Numerous evidence has attributed diets with a high fatty acids (FAs) intake to be associated with atopic dermatitis (AD) development. Therefore, this study investigated the association between intake frequencies of five dietary FAs and AD exacerbations among young Chinese adults from Singapore and Malaysia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A validated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was investigator-administered to 13,561 subjects to collect information on socioeconomic, anthropometric, dietary and lifestyles habits, and personal\/family medical histories. Six novel dietary indices were derived to analyse the associations between total FAs, trans fatty acids (TFAs), saturated fatty acids (SFAs), monounsaturated fatty acids, linoleic acids, and alpha-linolenic acids in diets and AD exacerbation. Synergy factor (SF) analysis was used to identify interactions between the dietary FAs to influence disease susceptibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In our multivariable model adjusted for age, gender, BMI, parental eczema, and lifestyle factors, a diet high in total estimated FAs was strongly associated with AD (Adjusted Odds Ratio (AOR): 1.227; 95% Confidence Interval (CI): 1.054\u20131.429; adjusted p-value &amp;lt;0.01). Particularly, high estimated total TFAs and SFAs were significantly associated with AD exacerbations including chronic and current moderate-to-severe AD. The association between TFAs and AD remained strong even controlled for the total FAs in diets and false discovery rate corrected (AOR: 1.516; 95% CI: 1.094\u20132.097; adjusted p-value &amp;lt;0.05). Similarly, having a high SFAs in diets was associated with AD (AOR: 1.581; 95% CI: 1.106\u20132.256; adjusted p-value &amp;lt;0.05) independently on the total FAs in diets. FAs in diets do not interact to influence AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, these results highlighted an association between high dietary TFAs and SFAs and AD exacerbations in an Asian population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ski2.330","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T01:45:29Z","timestamp":1719452729000},"source":"Crossref","is-referenced-by-count":11,"title":["Association of Frequent Intake of Trans Fatty Acids and Saturated Fatty Acids in Diets with Increased Susceptibility of Atopic Dermatitis Exacerbation in Young Chinese Adults: A Cross-Sectional Study in Singapore\/Malaysia"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-1749","authenticated-orcid":false,"given":"Jun Jie","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sing Wei","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1530-5934","authenticated-orcid":false,"given":"Kavita","family":"Reginald","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , Singapore ,","place":["Singapore"]},{"name":"Department of Biological Sciences, School of Medicine and Life Sciences, Sunway University , Petaling Jaya ,","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2363-5239","authenticated-orcid":false,"given":"Yee-How","family":"Say","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , Singapore ,","place":["Singapore"]},{"name":"Department of Biological Sciences, School of Medicine and Life Sciences, Sunway University , Petaling Jaya ,","place":["Malaysia"]},{"name":"Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR) , Kampar ,","place":["Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7405-7008","authenticated-orcid":false,"given":"Mei Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Food Science & Technology, Faculty of Science, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1337-5146","authenticated-orcid":false,"given":"Fook Tim","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , Singapore ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"issue":"12","key":"2025112605420763300_ski2330-bib-0001","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3511","article-title":"Counting the burden: atopic dermatitis and health-related quality of life","volume":"100","author":"Ali","year":"2020","journal-title":"Acta Derm Venereol"},{"issue":"2","key":"2025112605420763300_ski2330-bib-0002","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3892\/etm.2018.6980","article-title":"The impact of lifestyle factors on evolution of atopic dermatitis: an alternative approach","volume":"17","author":"Solomon","year":"2019","journal-title":"Exp Ther Med"},{"issue":"12","key":"2025112605420763300_ski2330-bib-0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100722","article-title":"An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore\/Malaysia Chinese young adult population: a detailed description of the Singapore\/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort","volume":"15","author":"Lim","year":"2022","journal-title":"World Allergy Organ J"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0004","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1272\/jnms.JNMS.2021_88-317","article-title":"Nutrition and atopic dermatitis","volume":"88","author":"Kanda","year":"2021","journal-title":"J Nippon Med Sch"},{"issue":"1","key":"2025112605420763300_ski2330-bib-0005","first-page":"1","article-title":"Skin and diet: an update on the role of dietary change as a treatment strategy for skin disease","volume":"23","author":"Katta","year":"2018","journal-title":"Skin Therapy Lett"},{"issue":"4","key":"2025112605420763300_ski2330-bib-0006","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1136\/thoraxjnl-2012-202285","article-title":"Do fast foods cause asthma, rhinoconjunctivitis and eczema? Global findings from the International Study of Asthma and Allergies in Childhood (ISAAC) phase three","volume":"68","author":"Ellwood","year":"2013","journal-title":"Thorax"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0007","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1183\/09031936.01.17304360","article-title":"Diet and asthma, allergic rhinoconjunctivitis and atopic eczema symptom prevalence: an ecological analysis of the International Study of Asthma and Allergies in Childhood (ISAAC) data. ISAAC Phase One Study Group","volume":"17","author":"Ellwood","year":"2001","journal-title":"Eur Respir J"},{"key":"2025112605420763300_ski2330-bib-0008","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02649","article-title":"Inflammatory links between high fat diets and diseases","volume":"9","author":"Duan","year":"2018","journal-title":"Front Immunol"},{"issue":"1 Suppl l","key":"2025112605420763300_ski2330-bib-0009","doi-asserted-by":"publisher","first-page":"367S","DOI":"10.1093\/ajcn\/71.1.367s","article-title":"Essential fatty acid metabolism and its modification in atopic eczema","volume":"71","author":"Horrobin","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"2025112605420763300_ski2330-bib-0010","doi-asserted-by":"publisher","first-page":"103","DOI":"10.5114\/pdia.2013.34160","article-title":"Supplementation with long chain polyunsaturated fatty acids in treatment of atopic dermatitis in children","volume":"30","author":"Kaczmarski","year":"2013","journal-title":"Postepy Dermatol Alergol"},{"issue":"5","key":"2025112605420763300_ski2330-bib-0011","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1034\/j.1398-9995.2001.056005425.x","article-title":"Diet, serum fatty acids, and atopic diseases in childhood","volume":"56","author":"Dunder","year":"2001","journal-title":"Allergy"},{"issue":"1","key":"2025112605420763300_ski2330-bib-0012","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92282-0","article-title":"Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s","volume":"11","author":"Kong","year":"2021","journal-title":"Sci Rep"},{"issue":"2","key":"2025112605420763300_ski2330-bib-0013","first-page":"194","article-title":"Intuitive eating and the nutrition transition in Asia","volume":"13","author":"Hawks","year":"2004","journal-title":"Asia Pac J Clin Nutr"},{"key":"2025112605420763300_ski2330-bib-0014","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000530948","article-title":"A dietary pattern for high estimated total fat amount is associated with enhanced allergy sensitization and atopic diseases among Singapore\/Malaysia young Chinese adults","author":"Lim","year":"2023","journal-title":"Int Arch Allergy Immunol"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0015","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1051\/animres:2000116","article-title":"Dietary fatty acids and human health","volume":"49","author":"Williams","year":"2000","journal-title":"Annales De Zootechnie"},{"issue":"5","key":"2025112605420763300_ski2330-bib-0016","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019719","article-title":"Genome-wide association study for atopy and allergic rhinitis in a Singapore Chinese population","volume":"6","author":"Andiappan","year":"2011","journal-title":"PLoS One"},{"key":"2025112605420763300_ski2330-bib-0017","author":"Singstat","year":"2020","journal-title":"Census of population 2020 statistical release"},{"issue":"2","key":"2025112605420763300_ski2330-bib-0018","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4103\/0253-7176.116232","article-title":"How to calculate sample size for different study designs in medical research?","volume":"35","author":"Charan","year":"2013","journal-title":"Indian J Psychol Med"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0019","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1365-2133.1994.tb08530.x","article-title":"The U.K. Working Party\u2019s Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis","volume":"131","author":"Williams","year":"1994","journal-title":"Br J Dermatol"},{"key":"2025112605420763300_ski2330-bib-0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/00015555924447","article-title":"Diagnostic features of atopic eczema","volume":"92","author":"Hanifin","year":"1980","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0021","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1183\/09031936.95.08030483","article-title":"International study of asthma and Allergies in childhood (ISAAC): rationale and methods","volume":"8","author":"Asher","year":"1995","journal-title":"Eur Respir J"},{"issue":"1","key":"2025112605420763300_ski2330-bib-0022","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ijc.2910320102","article-title":"Diet and colorectal cancer: a case-control study in Greece","volume":"32","author":"Manousos","year":"1983","journal-title":"Int J Cancer"},{"issue":"8","key":"2025112605420763300_ski2330-bib-0023","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.jclinepi.2014.03.012","article-title":"False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies","volume":"67","author":"Glickman","year":"2014","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"2025112605420763300_ski2330-bib-0024","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-2-105","article-title":"The synergy factor: a statistic to measure interactions in complex diseases","volume":"2","author":"Cortina-Borja","year":"2009","journal-title":"BMC Res Notes"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2022.100724","article-title":"Epidemiology of adult patients with atopic dermatitis in AWARE 1: a second international survey","volume":"16","author":"Maspero","year":"2023","journal-title":"World Allergy Organ J"},{"issue":"4","key":"2025112605420763300_ski2330-bib-0026","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.jaci.2019.12.899","article-title":"How does parental history of atopic disease predict the risk of atopic dermatitis in a child? A systematic review and meta-analysis","volume":"145","author":"Ravn","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"2025112605420763300_ski2330-bib-0027","first-page":"1","article-title":"Fats and fatty acids in human nutrition. Report of an expert consultation","volume":"91","year":"2010","journal-title":"FAO Food Nutr Pap"},{"key":"2025112605420763300_ski2330-bib-0028","journal-title":"National nutrition survey 2018 shows gradual improvements in Singaporeans\u2019 dietary habits"},{"key":"2025112605420763300_ski2330-bib-0029","author":"Health Promotion Board","year":"2010","journal-title":"Report of the national nutrition survey 2010; health promotion board: Singapore"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0030","doi-asserted-by":"publisher","first-page":"293S","DOI":"10.3945\/an.114.006940","article-title":"The science of fatty acids and inflammation","volume":"6","author":"Fritsche","year":"2015","journal-title":"Adv Nutr"},{"issue":"5","key":"2025112605420763300_ski2330-bib-0031","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.jaci.2013.12.1087","article-title":"Fatty acids, inflammation, and asthma","volume":"133","author":"Wendell","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"2025112605420763300_ski2330-bib-0032","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150202","article-title":"High-fat and low-carbohydrate diets are associated with allergic rhinitis but not asthma or atopic dermatitis in children","volume":"11","author":"Kim","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"2025112605420763300_ski2330-bib-0033","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1399-3038.2005.00366.x","article-title":"Margarine and butter consumption, eczema and allergic sensitization in children. The LISA birth cohort study","volume":"17","author":"Sausenthaler","year":"2006","journal-title":"Pediatr Allergy Immunol"},{"issue":"(Suppl 2)","key":"2025112605420763300_ski2330-bib-0034","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1038\/sj.ejcn.1602973","article-title":"Health effects of trans-fatty acids: experimental and observational evidence","volume":"63","author":"Mozaffarian","year":"2009","journal-title":"Eur J Clin Nutr"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0035","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1093\/jn\/135.3.562","article-title":"Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction","volume":"135","author":"Lopez-Garcia","year":"2005","journal-title":"J Nutr"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0036","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/1523-1747.ep12469875","article-title":"Increased interleukin 6 production by T cells derived from patients with atopic dermatitis","volume":"100","author":"Toshitani","year":"1993","journal-title":"J Invest Dermatol"},{"key":"2025112605420763300_ski2330-bib-0037","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12422.2","article-title":"Moderate-to-severe atopic dermatitis patients show increases in serum C-reactive protein levels, correlating with skin disease activity","volume":"6","author":"Vekaria","year":"2017","journal-title":"F1000Res"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0038","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/s0091-6749(97)70060-5","article-title":"Soluble E-selectin as a marker of disease activity in atopic dermatitis","volume":"99","author":"Yamashita","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"2025112605420763300_ski2330-bib-0039","author":"Health Hub Singapore","journal-title":"The skinny on trans fats"},{"key":"2025112605420763300_ski2330-bib-0040","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.atherosclerosis.2015.11.015","article-title":"Saturated fatty acids trigger TLR4-mediated inflammatory response","volume":"244","author":"Rocha","year":"2016","journal-title":"Atherosclerosis"},{"issue":"6","key":"2025112605420763300_ski2330-bib-0041","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0262-1746(82)90019-1","article-title":"Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy","volume":"9","author":"Manku","year":"1982","journal-title":"Prostaglandins Leukot Med"},{"issue":"10","key":"2025112605420763300_ski2330-bib-0042","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078245","article-title":"Gene expression of desaturase (FADS1 and FADS2) and Elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children","volume":"8","author":"Chisaguano","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"2025112605420763300_ski2330-bib-0043","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev.nutr.24.121803.063211","article-title":"Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases","volume":"24","author":"Nakamura","year":"2004","journal-title":"Annu Rev Nutr"},{"issue":"4","key":"2025112605420763300_ski2330-bib-0044","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/s0022-2275(20)31158-5","article-title":"Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts","volume":"42","author":"Williard","year":"2001","journal-title":"J Lipid Res"},{"issue":"1","key":"2025112605420763300_ski2330-bib-0045","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s0014-5793(01)03135-0","article-title":"Activity of human Delta5 and Delta6 desaturases on multiple n-3 and n-6 polyunsaturated fatty acids","volume":"509","author":"de Antueno","year":"2001","journal-title":"FEBS Lett"},{"key":"2025112605420763300_ski2330-bib-0046","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.plefa.2018.03.004","article-title":"Omega-6 fatty acids and inflammation","volume":"132","author":"Innes","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"3","key":"2025112605420763300_ski2330-bib-0047","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1159\/000087018","article-title":"Deficient production of hexadecenoic acid in the skin is associated in part with the vulnerability of atopic dermatitis patients to colonization by Staphylococcus aureus","volume":"211","author":"Takigawa","year":"2005","journal-title":"Dermatology"},{"key":"2025112605420763300_ski2330-bib-0048","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01949","article-title":"The role of lipid metabolism in T lymphocyte differentiation and survival","volume":"8","author":"Howie","year":"2018","journal-title":"Front Immunol"},{"issue":"7","key":"2025112605420763300_ski2330-bib-0049","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076302","article-title":"Gender-specific impact of sex hormones on the immune system","volume":"24","author":"Sciarra","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2025112605420763300_ski2330-bib-0050","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13293-015-0033-y","article-title":"Sex differences in metabolic homeostasis, diabetes, and obesity","volume":"6","author":"Mauvais-Jarvis","year":"2015","journal-title":"Biol Sex Differ"},{"issue":"7","key":"2025112605420763300_ski2330-bib-0051","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1007\/s00394-018-1810-2","article-title":"Effect of industrial trans-fatty acids-enriched diet on gut microbiota of C57BL\/6 mice","volume":"58","author":"Ge","year":"2019","journal-title":"Eur J Nutr"},{"issue":"44","key":"2025112605420763300_ski2330-bib-0052","doi-asserted-by":"publisher","first-page":"17808","DOI":"10.1073\/pnas.1312937110","article-title":"Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition","volume":"110","author":"Kishino","year":"2013","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/4\/ski2.330\/60660537\/skinhd_4_4_e330.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/4\/ski2.330\/60660537\/skinhd_4_4_e330.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:42:17Z","timestamp":1764153737000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/doi\/10.1002\/ski2.330\/7896786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,6,26]]},"published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ski2.330","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,6,26]]},"article-number":"ski2.330"}}