{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:53:43Z","timestamp":1774479223918,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":248,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hospital for Tropical Diseases Charitable Fund."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Leprosy is caused by Mycobacterium leprae. The condition primarily affects the skin and peripheral nerves. There are two types of leprosy reactions, Type 1 and Type 2 or erythema nodosum leprosum (ENL). ENL is a severe multi-system, immune-mediated complication of lepromatous leprosy. It is characterised by widespread painful cutaneous nodules, fever and peripheral oedema. This report discusses the unusual case of a 29-year-old woman who developed a localised form of ENL which required thalidomide to induce remission.<\/jats:p>","DOI":"10.1002\/ski2.339","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T02:00:03Z","timestamp":1707357603000},"source":"Crossref","is-referenced-by-count":3,"title":["Localised Erythema Nodosum Leprosum\u2014A Rare Entity Managed with Thalidomide"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5377-9089","authenticated-orcid":false,"given":"Chandni","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Healthcare Services for Elderly People, Royal Free Hospital, NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-8165","authenticated-orcid":false,"given":"Barbara","family":"De Barros","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust , London ,","place":["UK"]},{"name":"Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-8376","authenticated-orcid":false,"given":"Stephen L.","family":"Walker","sequence":"additional","affiliation":[{"name":"Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust , London ,","place":["UK"]},{"name":"Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine , London ,","place":["UK"]},{"name":"Department of Dermatology, University College London Hospitals NHS Foundation Trust , London ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"2025112605121158000_ski2339-bib-0001","volume-title":"Chapter 2.1. Clinical diagnosis of leprosy. International textbook of leprosy","author":"Kumar","year":"2017"},{"issue":"7","key":"2025112605121158000_ski2339-bib-0002","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0005716","article-title":"A leprosy clinical severity scale for erythema nodosum leprosum: an international, multicentre validation study of the ENLIST ENL severity scale","volume":"11","author":"Walker","year":"2017","journal-title":"PLoS Neglected Trop Dis"},{"key":"2025112605121158000_ski2339-bib-0003","volume-title":"Guidelines for the diagnosis, treatment and prevention of leprosy","author":"WHO Regional Office for South-East Asia","year":"2017"},{"issue":"MAR","key":"2025112605121158000_ski2339-bib-0004","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00233","article-title":"A systematic review of immunological studies of erythema nodosum leprosum","volume":"8","author":"Polycarpou","year":"2017","journal-title":"Front Immunol"},{"issue":"9","key":"2025112605121158000_ski2339-bib-0005","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004065","article-title":"ENLIST 1: an international multi-centre cross-sectional study of the clinical features of erythema nodosum leprosum","volume":"9","author":"Walker","year":"2015","journal-title":"PLoS Neglected Trop Dis"},{"issue":"5","key":"2025112605121158000_ski2339-bib-0006","doi-asserted-by":"publisher","first-page":"868","DOI":"10.4269\/ajtmh.2006.74.868","article-title":"Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India","volume":"74","author":"Pocaterra","year":"2006","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"2025112605121158000_ski2339-bib-0007","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1440-0960.2009.00534.x","article-title":"Comparative efficacy of thalidomide and prednisolone in the treatment of moderate to severe erythema nodosum leprosum: a randomized study","volume":"50","author":"Kaur","year":"2009","journal-title":"Australas J Dermatol"},{"key":"2025112605121158000_ski2339-bib-0008","volume-title":"International textbook of leprosy","author":"Walker","year":"2020"},{"issue":"2","key":"2025112605121158000_ski2339-bib-0009","doi-asserted-by":"publisher","first-page":"211","DOI":"10.47276\/lr.87.2.211","article-title":"Experiences with thalidomide for erythema nodosum leprosum\u2013 a retrospective study","volume":"87","author":"Darlong","year":"2016","journal-title":"Lepr Rev"},{"key":"2025112605121158000_ski2339-bib-0010","first-page":"252","volume-title":"Tropical dermatology","author":"Tyring","year":"2016","edition":"2nd ed"},{"issue":"2","key":"2025112605121158000_ski2339-bib-0011","doi-asserted-by":"publisher","first-page":"142","DOI":"10.47276\/lr.90.2.142","article-title":"A systematic review of adverse drug reactions associated with thalidomide in the treatment of erythema nodosum leprosum","volume":"90","author":"Mahmoud","year":"2019","journal-title":"Lepr Rev"},{"issue":"2","key":"2025112605121158000_ski2339-bib-0012","doi-asserted-by":"publisher","first-page":"221","DOI":"10.47276\/lr.87.2.221","article-title":"The use of steroids and thalidomide in the management of erythema nodosum leprosum; 17 years at the hospital for tropical diseases, London","volume":"87","author":"Nabarro","year":"2016","journal-title":"Lepr Rev"},{"issue":"1","key":"2025112605121158000_ski2339-bib-0013","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1489\/1544-581X(2003)71<10:ENLAOI>2.0.CO;2","article-title":"Erythema nodosum leprosum and orbital involvement","volume":"71","author":"Dhaliwal","year":"2003","journal-title":"Int J Lepr Other Mycobact Dis"},{"key":"2025112605121158000_ski2339-bib-0014","first-page":"237","volume-title":"Leprosy","author":"Pfalzgraff","year":"1994"},{"issue":"3","key":"2025112605121158000_ski2339-bib-0015","doi-asserted-by":"publisher","DOI":"10.5070\/d32xv335d1","article-title":"Localized and persistent erythema nodosum leprosum - a rare variant?","volume":"14","author":"Prabhu","year":"2008","journal-title":"Dermatol Online J"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/2\/ski2.339\/59729997\/skinhd_4_2_e339.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/2\/ski2.339\/59729997\/skinhd_4_2_e339.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:12:21Z","timestamp":1764151941000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/doi\/10.1002\/ski2.339\/7736683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2,7]]},"published-print":{"date-parts":[[2024,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ski2.339","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,2,7]]},"article-number":"ski2.339"}}