{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:42:24Z","timestamp":1765438944350,"version":"3.46.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":259,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hyperkeratosis of the nipples and areolae (HNA) is an uncommon skin disorder with no definite aetiology. We report a case of a 16-year-old boy, who presented with bilateral pigmentation and thickening of the nipples and areolae, accompanied with linear brown protrusions on the anterior neck and a velvet like appearance with pigmentation on the axillary bilaterlly. Based on clinical and histopathological, and dermatoscopic findings, the diagnosis of bilateral HNA accompanied by linear nevus and acanthosis nigricans was made. The skin lesions were improved by treatment with topical calcipotriol gel.<\/jats:p>","DOI":"10.1002\/ski2.344","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T05:15:07Z","timestamp":1706332507000},"source":"Crossref","is-referenced-by-count":2,"title":["Bilateral Hyperkeratosis of the Nipples and Areolae with Linear Nevus and Acanthosis Nigricans: A Rare Case Report"],"prefix":"10.1093","volume":"4","author":[{"given":"Rui-Ni","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology of Dingbian County Hospital , Shanxi ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Shun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology of Dingbian County Hospital , Shanxi ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology of Clinical Medical college of Yangzhou University , Jiangsu ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"2025112605120463900_ski2344-bib-0001","first-page":"388","article-title":"Hyperkeratosis in the region of the nipple and areola","volume":"8","author":"Oberste-Lehn","year":"1950","journal-title":"Z Haut-Geschlechtskr"},{"key":"2025112605120463900_ski2344-bib-0002","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.781693","article-title":"Severe bilateral hyperkeratosis of the nipples and areolae: a case report and literature review","volume":"9","author":"Wei-Ji","year":"2022","journal-title":"Front Med"},{"key":"2025112605120463900_ski2344-bib-0003","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.jclinepi.2017.04.026","article-title":"CARE guidelines for case reports: explanation and elaboration document","volume":"89","author":"Riley","year":"2017","journal-title":"J Clin Epidemiol"},{"key":"2025112605120463900_ski2344-bib-0004","first-page":"63","article-title":"Les hyperkeratoses de lareoie et du mamelon","volume":"28","author":"Levy-Franckel","year":"1938","journal-title":"Paris Med"},{"issue":"6","key":"2025112605120463900_ski2344-bib-0005","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.jdcr.2016.09.007","article-title":"Nevoid hyperkeratosis of the nipple mimicking a pigmented basal cell carcinoma","volume":"2","author":"Mazzella","year":"2016","journal-title":"JAAD Case Rep"},{"issue":"3","key":"2025112605120463900_ski2344-bib-0006","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1080\/00325481.2018.1446652","article-title":"Bilateral hyperkeratosis of the nipples and areolae with linear nevus: a rare case report and review of the literature","volume":"130","author":"Wang","year":"2018","journal-title":"PGM (Postgrad Med)"},{"key":"2025112605120463900_ski2344-bib-0007","first-page":"147","article-title":"Hyperkeratosis of thenipple and areola","volume":"40","author":"Obayashi","year":"1998","journal-title":"Rinsho Derma"},{"issue":"11","key":"2025112605120463900_ski2344-bib-0008","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1046\/j.1365-4362.2002.01656.x","article-title":"Nevoid hyperkeratosis of the nipple and\/or areola: are port of two cases and a review of the literature","volume":"41","author":"Krishnan","year":"2002","journal-title":"Int J Dermatol"},{"issue":"5","key":"2025112605120463900_ski2344-bib-0009","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13019","article-title":"Nevoid hyperkeratosis of male breast: successful treatment with minocycline","volume":"32","author":"Dabas","year":"2019","journal-title":"Dermatol Ther"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/2\/ski2.344\/59729950\/skinhd_4_2_e344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/2\/ski2.344\/59729950\/skinhd_4_2_e344.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:12:11Z","timestamp":1764151931000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/doi\/10.1002\/ski2.344\/7736688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,27]]},"references-count":9,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1,27]]},"published-print":{"date-parts":[[2024,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ski2.344","relation":{},"ISSN":["2690-442X"],"issn-type":[{"type":"electronic","value":"2690-442X"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,1,27]]},"article-number":"ski2.344"}}