{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:21:01Z","timestamp":1793985661718,"version":"4.8.0"},"reference-count":133,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":168,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["ISSF 204787\/Z\/16\/Z"],"award-info":[{"award-number":["ISSF 204787\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","award":["Seedcorn 2022\/100007"],"award-info":[{"award-number":["Seedcorn 2022\/100007"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012295","name":"NIHR Newcastle Biomedical Research Centre","doi-asserted-by":"publisher","award":["Infrastructural support"],"award-info":[{"award-number":["Infrastructural support"]}],"id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000774","name":"Newcastle University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Notoriously known as the silent pandemic, chronic, non-healing diabetic foot ulcers (DFUs), pose a significant rate of incidence for amputation and are a major cause of morbidity. Alarmingly, the treatment and management strategies of chronic wounds represent a significant economic and health burden as well as a momentous drain on resources with billions per annum being spent in the US and UK alone. Defective wound healing is a major pathophysiological condition which propagates an acute wound to a chronic wound, further propelled by underlying conditions such as diabetes and vascular complications which are more prevalent amongst the elderly. Chronic wounds are prone to infection, which can exacerbate the condition, occasionally resulting in amputation for the patient, despite the intervention of modern therapies. However, amputation can only yield a 5-year survival rate for 50% of patients, highlighting the need for new treatments for chronic wounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>The dynamic cutaneous microbiota is comprised of diverse microorganisms that often aid wound healing. Conversely, the chronic wound microbiome consists of a combination of common skin commensals such as Staphylococcus aureus and Staphylococcus epidermidis, as well as the opportunistic pathogen Pseudomonas aeruginosa. These bacteria have been identified as the most prevalent bacterial pathogens isolated from chronic wounds and contribute to prolific biofilm formation decreasing the efficiency of antimicrobials and further perpetuating a hyper-inflammatory state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and Conclusion<\/jats:title>\n                    <jats:p>Here, we review recent advances and provide a new perspective on alternative treatments including phage and microbiome transplant therapies and how the definitive role of the cutaneous microbiota impacts the aetiology of DFUs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ski2.399","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T17:14:56Z","timestamp":1717089296000},"source":"Crossref","is-referenced-by-count":21,"title":["Understanding and Treating Diabetic Foot Ulcers: Insights into the Role of Cutaneous Microbiota and Innovative Therapies"],"prefix":"10.1093","volume":"4","author":[{"given":"Paul","family":"Norton","sequence":"first","affiliation":[{"name":"School of Dental Sciences, Faculty of Medical Sciences, Newcastle University , Newcastle Upon Tyne ,","place":["UK"]},{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University , Newcastle Upon Tyne ,","place":["UK"]},{"name":"Centre for Skin Sciences, Faculty of Life Sciences, University of Bradford , Bradford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlos","family":"Trus","sequence":"additional","affiliation":[{"name":"School of Dental Sciences, Faculty of Medical Sciences, Newcastle University , Newcastle Upon Tyne ,","place":["UK"]},{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University , Newcastle Upon Tyne ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Dental Sciences, Faculty of Medical Sciences, Newcastle University , Newcastle Upon Tyne ,","place":["UK"]},{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University , Newcastle Upon Tyne ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Julie","family":"Thornton","sequence":"additional","affiliation":[{"name":"Centre for Skin Sciences, Faculty of Life Sciences, University of Bradford , Bradford ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3570-4019","authenticated-orcid":false,"given":"Chien-Yi","family":"Chang","sequence":"additional","affiliation":[{"name":"School of Dental Sciences, Faculty of Medical Sciences, Newcastle University , Newcastle Upon Tyne ,","place":["UK"]},{"name":"Biosciences Institute, Faculty of Medical Sciences, Newcastle University , Newcastle Upon Tyne ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"issue":"2","key":"2025112605420731800_ski2399-bib-0001","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/srt.12424","article-title":"The relationship between skin function, barrier properties, and body-dependent factors","volume":"24","author":"D\u0105browska","year":"2018","journal-title":"Skin Res Technol"},{"key":"2025112605420731800_ski2399-bib-0002","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jconrel.2016.08.007","article-title":"The role of tight junctions in skin barrier function and dermal absorption","volume":"242","author":"B\u00e4sler","year":"2016","journal-title":"J Control Release"},{"key":"2025112605420731800_ski2399-bib-0003","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.vph.2015.02.007","article-title":"The innate immune system, toll-like receptors and dermal wound healing: a review","volume":"71","author":"Portou","year":"2015","journal-title":"Vasc Pharmacol"},{"issue":"3","key":"2025112605420731800_ski2399-bib-0004","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","article-title":"Chronic wound healing: a review of current management and treatments","volume":"34","author":"Han","year":"2017","journal-title":"Adv Ther"},{"key":"2025112605420731800_ski2399-bib-0005","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2016.00082","article-title":"Biomaterials and Nanotherapeutics for enhancing skin wound healing","volume":"4","author":"Das","year":"2016","journal-title":"Front Bioeng Biotechnol"},{"issue":"6","key":"2025112605420731800_ski2399-bib-0006","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1080\/09537104.2018.1430357","article-title":"Platelets in wound healing and regenerative medicine","volume":"29","author":"Etulain","year":"2018","journal-title":"Platelets"},{"key":"2025112605420731800_ski2399-bib-0007","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00419","article-title":"The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes","volume":"9","author":"Krzyszczyk","year":"2018","journal-title":"Front Physiol"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0008","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14709","article-title":"Estimating the cost of wounds both nationally and regionally within the top 10 highest spenders","volume":"21","author":"Queen","year":"2024","journal-title":"Int Wound J"},{"issue":"6","key":"2025112605420731800_ski2399-bib-0009","doi-asserted-by":"publisher","first-page":"292","DOI":"10.12968\/jowc.2017.26.6.292","article-title":"The health economic burden that acute and chronic wounds impose on an average clinical commissioning group\/health board in the UK","volume":"26","author":"Guest","year":"2017","journal-title":"J Wound Care"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0010","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1111\/iwj.12926","article-title":"Role of anaerobes in polymicrobial communities and biofilms complicating diabetic foot ulcers","volume":"15","author":"Percival","year":"2018","journal-title":"Int Wound J"},{"key":"2025112605420731800_ski2399-bib-0011","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01791","article-title":"Microbiota of chronic diabetic wounds: ecology, impact, and potential for innovative treatment strategies","volume":"8","author":"Pereira","year":"2017","journal-title":"Front Microbiol"},{"issue":"(Suppl 1)","key":"2025112605420731800_ski2399-bib-0012","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1002\/dmrr.2707","article-title":"Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review","volume":"32","author":"Game","year":"2016","journal-title":"Diabetes Metab Res Rev"},{"issue":"9498","key":"2025112605420731800_ski2399-bib-0013","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/s0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"Falanga","year":"2005","journal-title":"Lancet"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0014","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/wrr.12738","article-title":"Effectiveness of biofilm-based wound care system on wound healing in chronic wounds","volume":"27","author":"Mori","year":"2019","journal-title":"Wound Repair Regen"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0015","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.pcd.2017.09.004","article-title":"Hidden dangers revealed by misdiagnosed diabetic neuropathy: a comparison of simple clinical tests for the screening of vibration perception threshold at primary care level","volume":"12","author":"Azzopardi","year":"2018","journal-title":"Primary Care Diabetes"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0016","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.dsx.2019.01.048","article-title":"Association of diabetic foot ulcers with chronic vascular diabetic complications in patients with type 2 diabetes","volume":"13","author":"Megallaa","year":"2019","journal-title":"Diabetes Metabol Syndr"},{"issue":"6","key":"2025112605420731800_ski2399-bib-0017","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jdiacomp.2019.02.006","article-title":"Can a combination of lifestyle and clinical characteristics explain the presence of foot ulcer in patients with diabetes?","volume":"33","author":"Naemi","year":"2019","journal-title":"J Diabetes Complicat"},{"issue":"2\u20134","key":"2025112605420731800_ski2399-bib-0018","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1053\/j.semvascsurg.2019.02.001","article-title":"The diabetic foot: pathophysiology, evaluation, and treatment","volume":"31","author":"Bandyk","year":"2018","journal-title":"Semin Vasc Surg"},{"issue":"9","key":"2025112605420731800_ski2399-bib-0019","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1161\/circresaha.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ Res"},{"issue":"7","key":"2025112605420731800_ski2399-bib-0020","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071419","article-title":"Diabetes and wound angiogenesis","volume":"18","author":"Okonkwo","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2025112605420731800_ski2399-bib-0021","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.2337\/db14-1111","article-title":"High levels of pigment epithelium-derived factor in diabetes impair wound healing through suppression of Wnt signaling","volume":"64","author":"Qi","year":"2015","journal-title":"Diabetes"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0022","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cjtee.2021.07.004","article-title":"Therapeutic strategies for chronic wound infection","volume":"25","author":"Liu","year":"2022","journal-title":"Chin J Traumatol"},{"issue":"46","key":"2025112605420731800_ski2399-bib-0023","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5569","article-title":"Lack of nutritional immunity in diabetic skin infections promotes Staphylococcus aureus virulence","volume":"6","author":"Thurlow","year":"2020","journal-title":"Sci Adv"},{"issue":"4","key":"2025112605420731800_ski2399-bib-0024","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.jpain.2005.12.002","article-title":"The prevalence and occurrence of diabetic foot ulcer pain and its impact on health-related quality of life","volume":"7","author":"Ribu","year":"2006","journal-title":"J Pain"},{"issue":"4","key":"2025112605420731800_ski2399-bib-0025","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1097\/01.asw.0000550591.08674.98","article-title":"Plantar ulcers and neuropathic arthropathies: associated diseases, polyneuropathy correlates, and risk covariates","volume":"32","author":"Andrews","year":"2019","journal-title":"Adv Skin Wound Care"},{"issue":"10","key":"2025112605420731800_ski2399-bib-0026","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.2337\/diacare.25.10.1835","article-title":"Diabetic neuropathic foot ulcers: the association of wound size, wound duration, and wound grade on healing","volume":"25","author":"Margolis","year":"2002","journal-title":"Diabetes Care"},{"issue":"9","key":"2025112605420731800_ski2399-bib-0027","doi-asserted-by":"publisher","first-page":"280","DOI":"10.4066\/amj.2015.2422","article-title":"Spectrum of bacteria associated with diabetic foot ulcer and biofilm formation: a prospective study","volume":"8","author":"Banu","year":"2015","journal-title":"Australas Med J"},{"issue":"8","key":"2025112605420731800_ski2399-bib-0028","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183777","article-title":"Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"issue":"11","key":"2025112605420731800_ski2399-bib-0029","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1089\/wound.2014.0530","article-title":"Nutrition and chronic wounds","volume":"3","author":"Molnar","year":"2014","journal-title":"Adv Wound Care"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0030","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13098-018-0311-z","article-title":"Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients","volume":"10","author":"Stefanadi","year":"2018","journal-title":"Diabetol Metab Syndr"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0031","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","article-title":"Wound healing - a literature review","volume":"91","author":"Gonzalez","year":"2016","journal-title":"An Bras Dermatol"},{"key":"2025112605420731800_ski2399-bib-0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.103987","article-title":"The role of circulating soluble fms-like tyrosine kinase-1 in patients with diabetic foot ulcer: a possible mechanism of pathogenesis via a novel link between oxidative stress, inflammation and angiogenesis","volume":"130","author":"Abd El-Khalik","year":"2020","journal-title":"Microvasc Res"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0033","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12964-019-0376-9","article-title":"Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization","volume":"17","author":"Feng","year":"2019","journal-title":"Cell Commun Signal"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0034","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/nyas.13926","article-title":"The role of the microbiome in nonhealing diabetic wounds","volume":"1435","author":"Kalan","year":"2019","journal-title":"Ann N Y Acad Sci"},{"issue":"3 Suppl l","key":"2025112605420731800_ski2399-bib-0035","doi-asserted-by":"publisher","first-page":"18S","DOI":"10.1097\/prs.0000000000002682","article-title":"Biology and biomarkers for wound healing","volume":"138","author":"Lindley","year":"2016","journal-title":"Plast Reconstr Surg"},{"issue":"6","key":"2025112605420731800_ski2399-bib-0036","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1161\/atvbaha.114.305048","article-title":"Impairment of wound healing in patients with type 2 diabetes Mellitus influences circulating MicroRNA patterns via inflammatory cytokines","volume":"35","author":"Dangwal","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0037","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.jdiacomp.2014.11.015","article-title":"Genetic and epigenetic alterations in Toll like receptor 2 and wound healing impairment in type 2 diabetes patients","volume":"29","author":"Singh","year":"2015","journal-title":"J Diabetes Complicat"},{"key":"2025112605420731800_ski2399-bib-0038","article-title":"Genetic alterations in toll-like receptor 4 signaling pathway and impairment of wound healing in patients with type 2 diabetes - Kanhaiya Singh","author":"Kumar Singh","year":"2014","journal-title":"Kiran Singh"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0039","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s40168-019-0709-3","article-title":"Skin microbiome modulation induced by probiotic solutions","volume":"7","author":"Paetzold","year":"2019","journal-title":"Microbiome"},{"key":"2025112605420731800_ski2399-bib-0040","journal-title":"Gut microbiome transition across a lifestyle gradient in Himalaya - PubMed"},{"issue":"3","key":"2025112605420731800_ski2399-bib-0041","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cell.2019.01.001","article-title":"Extensive unexplored human microbiome diversity revealed by over 150,000 genomes from metagenomes spanning age, geography, and lifestyle","volume":"176","author":"Pasolli","year":"2019","journal-title":"Cell"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0042","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1175-y","article-title":"Influence of diet on the gut microbiome and implications for human health","volume":"15","author":"Singh","year":"2017","journal-title":"J Transl Med"},{"issue":"4","key":"2025112605420731800_ski2399-bib-0043","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.cell.2016.04.008","article-title":"Temporal stability of the human skin microbiome","volume":"165","author":"Oh","year":"2016","journal-title":"Cell"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0044","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1016\/j.jid.2016.07.045","article-title":"The molecular revolution in cutaneous biology: investigating the skin microbiome","volume":"137","author":"Kong","year":"2017","journal-title":"J Invest Dermatol"},{"issue":"8","key":"2025112605420731800_ski2399-bib-0045","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012277","article-title":"Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne","volume":"5","author":"Lomholt","year":"2010","journal-title":"PLoS One"},{"issue":"7","key":"2025112605420731800_ski2399-bib-0046","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1089\/wound.2012.0397","article-title":"The wound microbiome: modern approaches to examining the role of microorganisms in impaired chronic wound healing","volume":"3","author":"Misic","year":"2014","journal-title":"Adv Wound Care"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0047","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000713","article-title":"Characterization of the oral fungal microbiome (mycobiome) in healthy individuals","volume":"6","author":"Ghannoum","year":"2010","journal-title":"PLoS Pathog"},{"issue":"4","key":"2025112605420731800_ski2399-bib-0048","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/nrmicro2537","article-title":"The skin microbiome","volume":"9","author":"Grice","year":"2011","journal-title":"Nat Rev Microbiol"},{"issue":"5931","key":"2025112605420731800_ski2399-bib-0049","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1126\/science.1171700","article-title":"Topographical and temporal diversity of the human skin microbiome","volume":"324","author":"Grice","year":"2009","journal-title":"Science"},{"issue":"3 Pt 2","key":"2025112605420731800_ski2399-bib-0050","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/jid.2011.417","article-title":"Skin microbiome: looking back to move forward","volume":"132","author":"Kong","year":"2012","journal-title":"J Invest Dermatol"},{"key":"2025112605420731800_ski2399-bib-0051","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coi.2016.05.002","article-title":"Atopic dermatitis and filaggrin","volume":"42","author":"Cabanillas","year":"2016","journal-title":"Curr Opin Immunol"},{"issue":"9","key":"2025112605420731800_ski2399-bib-0052","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/1346-8138.14952","article-title":"Skin microbiome differences relate to the grade of acne vulgaris","volume":"46","author":"Li","year":"2019","journal-title":"J Dermatol"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0053","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-4-33","article-title":"Role of the skin microbiome in atopic dermatitis","volume":"4","author":"Salava","year":"2014","journal-title":"Clin Transl Allergy"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0054","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01315-15","article-title":"The human skin microbiome associates with the outcome of and is influenced by bacterial infection","volume":"6","author":"van Rensburg","year":"2015","journal-title":"mBio"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0055","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53266-3","article-title":"Segregation of age-related skin microbiome characteristics by functionality","volume":"9","author":"Kim","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"2025112605420731800_ski2399-bib-0056","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.jaad.2006.12.004","article-title":"Obesity and the skin: skin physiology and skin manifestations of obesity","volume":"56","author":"Yosipovitch","year":"2007","journal-title":"J Am Acad Dermatol"},{"issue":"Suppl 10","key":"2025112605420731800_ski2399-bib-0057","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.12968\/jowc.2018.27.sup10.s10","article-title":"Use of wet-to-moist cleansing with different irrigation solutions to reduce bacterial bioburden in chronic wounds","volume":"27","author":"Assadian","year":"2018","journal-title":"J Wound Care"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0058","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1111\/j.1524-475x.2012.00836.x","article-title":"A review of the scientific evidence for biofilms in wounds","volume":"20","author":"Percival","year":"2012","journal-title":"Wound Repair Regen"},{"key":"2025112605420731800_ski2399-bib-0059","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3543","article-title":"A longitudinal study of the diabetic skin and wound microbiome","volume":"5","author":"Gardiner","year":"2017","journal-title":"PeerJ"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0060","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.dsx.2017.08.008","article-title":"Clinical and microbiological profile of diabetic foot ulcer patients in a tertiary care hospital","volume":"12","author":"Kateel","year":"2018","journal-title":"Diabetes Metabol Syndr"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0061","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/wrr.12370","article-title":"Analysis of the chronic wound microbiota of 2,963 patients by 16S rDNA pyrosequencing","volume":"24","author":"Wolcott","year":"2016","journal-title":"Wound Repair Regen"},{"issue":"3","key":"2025112605420731800_ski2399-bib-0062","doi-asserted-by":"publisher","first-page":"923","DOI":"10.2337\/db12-0771","article-title":"The neuropathic diabetic foot ulcer microbiome is associated with clinical factors","volume":"62","author":"Gardner","year":"2013","journal-title":"Diabetes"},{"key":"2025112605420731800_ski2399-bib-0063","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00282","article-title":"Exploring the microbiota of diabetic foot infections with culturomics","volume":"8","author":"Jneid","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"issue":"7689","key":"2025112605420731800_ski2399-bib-0064","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature25177","article-title":"Skin microbiota-host interactions","volume":"553","author":"Chen","year":"2018","journal-title":"Nature"},{"issue":"8","key":"2025112605420731800_ski2399-bib-0065","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/nrmicro2182","article-title":"Staphylococcus epidermidis--the \u2018accidental\u2019 pathogen","volume":"7","author":"Otto","year":"2009","journal-title":"Nat Rev Microbiol"},{"issue":"11","key":"2025112605420731800_ski2399-bib-0066","doi-asserted-by":"publisher","DOI":"10.1128\/jb.00174-22","article-title":"Investigation of the mechanism and chemistry underlying Staphylococcus aureus\u2019 ability to inhibit Pseudomonas aeruginosa growth in vitro","volume":"204","author":"Kvich","year":"2022","journal-title":"J Bacteriol"},{"issue":"22","key":"2025112605420731800_ski2399-bib-0067","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1097\/cm9.0000000000000523","article-title":"Chronic wound biofilms: diagnosis and therapeutic strategies","volume":"132","author":"Wei","year":"2019","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0068","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/1751-7915.12316","article-title":"A novel bacteriophage cocktail reduces and disperses Pseudomonas aeruginosa biofilms under static and flow conditions","volume":"9","author":"Alves","year":"2016","journal-title":"Microb Biotechnol"},{"issue":"4","key":"2025112605420731800_ski2399-bib-0069","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.ijantimicag.2009.12.011","article-title":"Antibiotic resistance of bacterial biofilms","volume":"35","author":"H\u00f8iby","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"2025112605420731800_ski2399-bib-0070","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02671","article-title":"Surface sensing for biofilm formation in Pseudomonas aeruginosa","volume":"8","author":"Chang","year":"2017","journal-title":"Front Microbiol"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0071","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5462","article-title":"Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles","volume":"5","author":"Chua","year":"2014","journal-title":"Nat Commun"},{"issue":"19","key":"2025112605420731800_ski2399-bib-0072","doi-asserted-by":"publisher","first-page":"8825","DOI":"10.1021\/acs.jmedchem.8b01005","article-title":"Validation of matrix metalloproteinase-9 (MMP-9) as a novel target for treatment of diabetic foot ulcers in humans and discovery of a potent and selective small-molecule MMP-9 inhibitor that accelerates healing","volume":"61","author":"Nguyen","year":"2018","journal-title":"J Med Chem"},{"issue":"3","key":"2025112605420731800_ski2399-bib-0073","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/dth.12055","article-title":"Dressings for chronic wounds","volume":"26","author":"Powers","year":"2013","journal-title":"Dermatol Ther"},{"key":"2025112605420731800_ski2399-bib-0074","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.colsurfb.2018.03.008","article-title":"Polydimethylsiloxane incorporated with reduced graphene oxide (rGO) sheets for wound dressing application: preparation and characterization","volume":"166","author":"Qian","year":"2018","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0075","doi-asserted-by":"publisher","DOI":"10.3390\/s19050991","article-title":"Two-layer electrospun system enabling wound exudate management and visual infection response","volume":"19","author":"Bazbouz","year":"2019","journal-title":"Sensors"},{"issue":"3","key":"2025112605420731800_ski2399-bib-0076","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1128\/mmbr.00013-14","article-title":"Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics","volume":"78","author":"Lebeaux","year":"2014","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0077","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12866-018-1183-y","article-title":"Susceptibility patterns and the role of extracellular DNA in Staphylococcus epidermidis biofilm resistance to physico-chemical stress exposure","volume":"18","author":"Olwal","year":"2018","journal-title":"BMC Microbiol"},{"key":"2025112605420731800_ski2399-bib-0078","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.micpath.2016.02.009","article-title":"Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them","volume":"95","author":"Khameneh","year":"2016","journal-title":"Microb Pathog"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0079","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1078\/1438-4221-00196","article-title":"Mechanisms of antibiotic resistance in bacterial biofilms","volume":"292","author":"Stewart","year":"2002","journal-title":"Int J Med Microbiol"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0080","first-page":"269","article-title":"Vancomycin resistance in Staphylococcus aureus","volume":"90","author":"McGuinness","year":"2017","journal-title":"Yale J Biol Med"},{"issue":"6","key":"2025112605420731800_ski2399-bib-0081","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1080\/21505594.2016.1250995","article-title":"Blue light treatment of Pseudomonas aeruginosa: Strong bactericidal activity, synergism with antibiotics and inactivation of virulence factors","volume":"8","author":"Fila","year":"2017","journal-title":"Virulence"},{"issue":"9","key":"2025112605420731800_ski2399-bib-0082","doi-asserted-by":"publisher","DOI":"10.3390\/nano8090681","article-title":"Biomedical applications of silver nanoparticles: an up-to-date overview","volume":"8","author":"Burdu\u0219el","year":"2018","journal-title":"Nanomaterials"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0083","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12951-018-0334-5","article-title":"A review on biosynthesis of silver nanoparticles and their biocidal properties","volume":"16","author":"Siddiqi","year":"2018","journal-title":"J Nanobiotechnology"},{"key":"2025112605420731800_ski2399-bib-0084","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.2147\/ijn.s121956","article-title":"The antimicrobial activity of nanoparticles: present situation and prospects for the future","volume":"12","author":"Wang","year":"2017","journal-title":"Int J Nanomedicine"},{"issue":"2\u20133","key":"2025112605420731800_ski2399-bib-0085","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/s0168-6445(03)00047-0","article-title":"Bacterial silver resistance: molecular biology and uses and misuses of silver compounds","volume":"27","author":"Silver","year":"2003","journal-title":"FEMS Microbiol Rev"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0086","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1111\/iwj.14018","article-title":"A long-term follow-up study of diabetic foot ulcer using micronized acellular dermal matrix","volume":"20","author":"Byeon","year":"2022","journal-title":"Int Wound J"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0087","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/dom.14840","article-title":"Global mortality of diabetic foot ulcer: a systematic review and meta-analysis of observational studies","volume":"25","author":"Chen","year":"2023","journal-title":"Diabetes Obes Metab"},{"key":"2025112605420731800_ski2399-bib-0088","journal-title":"WHO publishes list of bacteria for which new antibiotics are urgently needed"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0089","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-020-01891-8","article-title":"Efficacy of phage cocktail AB-SA01 therapy in diabetic mouse wound infections caused by multidrug-resistant Staphylococcus aureus","volume":"20","author":"Kifelew","year":"2020","journal-title":"BMC Microbiol"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0090","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-35364-5","article-title":"Bacteriophage-loaded functional nanofibers for treatment of P. aeruginosa and S. aureus wound infections","volume":"13","author":"Kielholz","year":"2023","journal-title":"Sci Rep"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0091","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s10123-022-00293-2","article-title":"Bacteriophage therapy as an alternative technique for treatment of multidrug-resistant bacteria causing diabetic foot infection","volume":"26","author":"Ghanaim","year":"2023","journal-title":"Int Microbiol"},{"issue":"3","key":"2025112605420731800_ski2399-bib-0092","doi-asserted-by":"publisher","first-page":"162","DOI":"10.4292\/wjgpt.v8.i3.162","article-title":"Phage therapy: an alternative to antibiotics in the age of multi-drug resistance","volume":"8","author":"Lin","year":"2017","journal-title":"World J Gastrointest Pharmacol Ther"},{"issue":"4","key":"2025112605420731800_ski2399-bib-0093","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s11262-023-02004-z","article-title":"Antibacterial effects of single phage and phage cocktail against multidrug-resistant Klebsiella pneumoniae isolated from diabetic foot ulcer","volume":"59","author":"Jokar","year":"2023","journal-title":"Virus Gene"},{"issue":"4","key":"2025112605420731800_ski2399-bib-0094","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040564","article-title":"An enzybiotic cocktail effectively disrupts preformed dual biofilm of Staphylococcus aureus and Enterococcus faecalis","volume":"16","author":"Manoharadas","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0095","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1007\/s00253-015-7247-0","article-title":"Bacteriophage-encoded depolymerases: their diversity and biotechnological applications","volume":"100","author":"Pires","year":"2016","journal-title":"Appl Microbiol Biotechnol"},{"key":"2025112605420731800_ski2399-bib-0096","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01251","article-title":"Synergy between two chimeric lysins to kill Streptococcus pneumoniae","volume":"10","author":"V\u00e1zquez","year":"2019","journal-title":"Front Microbiol"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0097","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10020175","article-title":"Bacteriophage-derived depolymerases against bacterial biofilm","volume":"10","author":"Topka-Bielecka","year":"2021","journal-title":"Antibiotics (Basel)"},{"issue":"8","key":"2025112605420731800_ski2399-bib-0098","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1086\/521305","article-title":"Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage phi MR11","volume":"196","author":"Rashel","year":"2007","journal-title":"J Infect Dis"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0099","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056022","article-title":"Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections","volume":"8","author":"Chhibber","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"2025112605420731800_ski2399-bib-0100","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1001\/jamaoto.2019.1191","article-title":"Safety and tolerability of bacteriophage therapy for chronic rhinosinusitis due to Staphylococcus aureus","volume":"145","author":"Ooi","year":"2019","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"Suppl ment_5","key":"2025112605420731800_ski2399-bib-0101","doi-asserted-by":"publisher","first-page":"S433","DOI":"10.1093\/cid\/ciad483","article-title":"Therapeutic phages as modulators of the immune response: Practical implications","volume":"77","author":"G\u00f3rski","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2025112605420731800_ski2399-bib-0102","article-title":"Does treatment order matter? Investigating the ability of bacteriophage to augment antibiotic activity against Staphylococcus aureus biofilms","volume":"9","author":"Kumaran","year":"2018","journal-title":"Frontiers in Microbiology [Internet]"},{"key":"2025112605420731800_ski2399-bib-0103","journal-title":"Design of phage-cocktail-containing hydrogel for the treatment of Pseudomonas aeruginosa-infected wounds - PubMed"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0104","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168615","article-title":"Synergy and order effects of antibiotics and phages in killing Pseudomonas aeruginosa biofilms","volume":"12","author":"Chaudhry","year":"2017","journal-title":"PLoS One"},{"issue":"6379","key":"2025112605420731800_ski2399-bib-0105","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4120","article-title":"Systematic discovery of antiphage defense systems in the microbial pangenome","volume":"359","author":"Doron","year":"2018","journal-title":"Science"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0106","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/s41564-017-0051-0","article-title":"DISARM is a widespread bacterial defence system with broad anti-phage activities","volume":"3","author":"Ofir","year":"2018","journal-title":"Nat Microbiol"},{"issue":"7","key":"2025112605420731800_ski2399-bib-0107","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/s41564-020-0700-6","article-title":"SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities","volume":"5","author":"Xiong","year":"2020","journal-title":"Nat Microbiol"},{"issue":"8","key":"2025112605420731800_ski2399-bib-0108","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13338","article-title":"The selective advantage of facultative anaerobes relies on their unique ability to cope with changing oxygen levels during infection","volume":"23","author":"Andr\u00e9","year":"2021","journal-title":"Cell Microbiol"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0109","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021004","article-title":"Biofilms in chronic wound infections: Innovative antimicrobial approaches using the in vitro lubbock chronic wound biofilm model","volume":"24","author":"Diban","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"18","key":"2025112605420731800_ski2399-bib-0110","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810761","article-title":"Polymicrobial biofilm organization of Staphylococcus aureus and Pseudomonas aeruginosa in a chronic wound environment","volume":"23","author":"Pouget","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0111","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.chom.2021.03.003","article-title":"Bacteria induce skin regeneration via IL-1\u03b2 signaling","volume":"29","author":"Wang","year":"2021","journal-title":"Cell Host Microbe"},{"issue":"7","key":"2025112605420731800_ski2399-bib-0112","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1128\/jcm.00743-16","article-title":"Significance of Staphylococcus epidermidis in health care-associated infections, from contaminant to clinically relevant pathogen: this is a wake-up call","volume":"54","author":"Widerstr\u00f6m","year":"2016","journal-title":"J Clin Microbiol"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0113","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1089\/wound.2013.0520","article-title":"The role of hypoxia-inducible factor in wound healing","volume":"3","author":"Hong","year":"2014","journal-title":"Adv Wound Care"},{"key":"2025112605420731800_ski2399-bib-0114","journal-title":"Role of wound microbiome, strategies of microbiota delivery system and clinical management - PubMed"},{"key":"2025112605420731800_ski2399-bib-0115","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114671","article-title":"Role of wound microbiome, strategies of microbiota delivery system and clinical management","volume":"192","author":"Tang","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"issue":"40","key":"2025112605420731800_ski2399-bib-0116","doi-asserted-by":"publisher","first-page":"17187","DOI":"10.1073\/pnas.0904847106","article-title":"Human gut microbiome adopts an alternative state following small bowel transplantation","volume":"106","author":"Hartman","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"2025112605420731800_ski2399-bib-0117","doi-asserted-by":"publisher","DOI":"10.3390\/cells11172718","article-title":"Targeting the gut microbiome to treat metabolic dysfunction-associated fatty liver disease: Ready for prime time?","volume":"11","author":"Lanthier","year":"2022","journal-title":"Cells"},{"issue":"7","key":"2025112605420731800_ski2399-bib-0118","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000801","article-title":"Successful fecal microbiota transplant delivered by foley catheter through a loop ileostomy in a patient with severe complicated clostridioides difficile infection","volume":"9","author":"Philip","year":"2022","journal-title":"ACG Case Rep J"},{"issue":"18","key":"2025112605420731800_ski2399-bib-0119","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.3889\/oamjms.2019.827","article-title":"Gut microbiota and the alteration of immune balance in skin diseases: from nutraceuticals to fecal transplantation","volume":"7","author":"Vojvodic","year":"2019","journal-title":"Open Access Maced J Med Sci"},{"issue":"8","key":"2025112605420731800_ski2399-bib-0120","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1089\/sur.2018.231","article-title":"Probiotics in prevention of surgical site infections","volume":"19","author":"Siddharthan","year":"2018","journal-title":"Surg Infect"},{"key":"2025112605420731800_ski2399-bib-0121","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114727","article-title":"Colonizing microbiota is associated with clinical outcomes in diabetic wound healing","volume":"194","author":"Wang","year":"2023","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"2025112605420731800_ski2399-bib-0122","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041218","article-title":"The wound microbiome","volume":"15","author":"White","year":"2023","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"2025112605420731800_ski2399-bib-0123","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07368-7","article-title":"Disease-associated genotypes of the commensal skin bacterium Staphylococcus epidermidis","volume":"9","author":"M\u00e9ric","year":"2018","journal-title":"Nat Commun"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0124","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.chom.2019.03.006","article-title":"Strain- and species-level variation in the microbiome of diabetic wounds is associated with clinical outcomes and therapeutic efficacy","volume":"25","author":"Kalan","year":"2019","journal-title":"Cell Host Microbe"},{"key":"2025112605420731800_ski2399-bib-0125","journal-title":"Retrospective comparison of negative pressure wound therapy and silver-coated foam dressings in open-wound treatment in cats - PubMed"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0126","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.12669\/pjms.335.11509","article-title":"Effect of oil gauze silver dressings on diabetic foot ulcers in the elderly","volume":"33","author":"Dong","year":"2017","journal-title":"Pak J Med Sci"},{"issue":"6","key":"2025112605420731800_ski2399-bib-0127","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1177\/1098612x16645141","article-title":"Retrospective comparison of negative pressure wound therapy and silver-coated foam dressings in open-wound treatment in cats","volume":"19","author":"Nolff","year":"2017","journal-title":"J Feline Med Surg"},{"issue":"5","key":"2025112605420731800_ski2399-bib-0128","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1097\/won.0000000000000358","article-title":"Effectiveness and value of prophylactic 5-layer foam sacral dressings to prevent hospital-acquired pressure injuries in acute care hospitals: an observational cohort study","volume":"44","author":"Padula","year":"2017","journal-title":"J Wound Ostomy Continence Nurs"},{"issue":"2","key":"2025112605420731800_ski2399-bib-0129","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.xphs.2017.09.026","article-title":"Composite alginate-hyaluronan sponges for the delivery of tranexamic acid in postextractive alveolar wounds","volume":"107","author":"Catanzano","year":"2018","journal-title":"J Pharm Sci"},{"issue":"18","key":"2025112605420731800_ski2399-bib-0130","doi-asserted-by":"publisher","first-page":"10638","DOI":"10.1039\/c6ra25340g","article-title":"Wound dressing application of pH-sensitive carbon dots\/chitosan hydrogel","volume":"7","author":"Omidi","year":"2017","journal-title":"RSC Adv"},{"issue":"12","key":"2025112605420731800_ski2399-bib-0131","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123383","article-title":"Biodegradable and pH sensitive peptide based hydrogel as controlled release system for antibacterial wound dressing application","volume":"23","author":"Zhu","year":"2018","journal-title":"Molecules"},{"key":"2025112605420731800_ski2399-bib-0132","journal-title":"Controlled release of chitosan and sericin from the microspheres-embedded wound dressing for the prolonged anti-microbial and wound healing efficacy - PubMed"},{"issue":"6","key":"2025112605420731800_ski2399-bib-0133","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1007\/s00289-016-1840-y","article-title":"Characterization and evaluation of siderophore-loaded gelatin microspheres: a potent tool for wound-dressing material","volume":"74","author":"Thyagarajan","year":"2017","journal-title":"Polym Bull"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/4\/ski2.399\/60660742\/skinhd_4_4_e399.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/4\/ski2.399\/60660742\/skinhd_4_4_e399.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:42:16Z","timestamp":1764153736000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/doi\/10.1002\/ski2.399\/7896835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":133,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,5,30]]},"published-print":{"date-parts":[[2024,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ski2.399","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,5,30]]},"article-number":"ski2.399"}}