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The histopathological examination (HPE), supplemented with special stains confirmed the diagnosis of cutaneous leiomyoma (CL). The immunohistochemical analysis showed a strong expression of smooth muscle actin. The final diagnosis of sporadic diffuse multiple cutaneous leiomyomatosis was made. This presentation of CL is uncommon and resembled plexiform neurofibroma. The clinical diagnosis of this presentation was challenging. Therefore, HPE combined with special stains aided in confirming this surgically challenging rare tumour. In resource-poor settings regular screening is required for early detection of renal cancer and other associated complications.<\/jats:p>","DOI":"10.1002\/ski2.414","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T12:39:38Z","timestamp":1722515978000},"source":"Crossref","is-referenced-by-count":0,"title":["A Sporadic Diffuse Multiple Cutaneous Leiomyomatosis Mimicking Plexiform Neurofibromatosis: A Surgical Challenge"],"prefix":"10.1093","volume":"4","author":[{"given":"Gajanand M.","family":"Antakanavar","sequence":"first","affiliation":[{"name":"Department of Dermatology, Maulana Azad Medical College , New Delhi ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijaylaxmi","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Maulana Azad Medical College , New Delhi ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Maulana Azad Medical College , New Delhi ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishu","family":"Ghiloria","sequence":"additional","affiliation":[{"name":"Department of Pathology, Maulana Azad Medical College , New Delhi ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Jangid","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maulana Azad Medical College , New Delhi ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavishya","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Maulana Azad Medical College , New Delhi ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"issue":"3","key":"2025112605515770400_ski2414-bib-0001","doi-asserted-by":"publisher","first-page":"245","DOI":"10.4103\/0019-5154.110881","article-title":"A generalized multiple cutaneous piloleiomyomatosis in a young male: rare case report","volume":"58","author":"Kudur","year":"2013","journal-title":"Indian J Dermatol"},{"issue":"5","key":"2025112605515770400_ski2414-bib-0002","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/j.1525-1470.2009.01000.x","article-title":"Solitary cutaneous leiomyoma in an infant","volume":"26","author":"Robati","year":"2009","journal-title":"Pediatr Dermatol"},{"issue":"12","key":"2025112605515770400_ski2414-bib-0003","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1111\/j.1346-8138.2001.tb00073.x","article-title":"Zosteriform pilar leiomyoma","volume":"28","author":"Sahoo","year":"2001","journal-title":"J Dermatol"},{"issue":"3 Suppl 1","key":"2025112605515770400_ski2414-bib-0004","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1590\/abd1806-4841.20153769","article-title":"Piloleiomyoma with segmental distribution - 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