{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:17:04Z","timestamp":1779347824877,"version":"3.51.4"},"reference-count":3,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":118,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016646","name":"HCA Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016646","id-type":"DOI","asserted-by":"publisher"}]},{"name":"HCA Healthcare affiliated entity"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Clear cell renal cell carcinoma (ccRCC) is a highly lethal cancer known for its propensity to metastasise, yet the mechanisms underlying metastasis are not well defined. Cutaneous metastases from ccRCC are uncommon and typically occur within 3 years post-nephrectomy, predominantly affecting the scalp, chest or abdomen. Here, we present a unique case of a 75-year-old male, previously treated for ccRCC with right radical nephrectomy, who developed a singular skin lesion on the left side of the neck 19 years post-nephrectomy. The lesion was confirmed as metastatic ccRCC through histopathological analysis, despite negative imaging findings. Micrometastases, characterised by microscopic tumour cell foci in distant sites, pose a significant diagnostic challenge, frequently evading detection on conventional imaging modalities like computed tomography and magnetic resonance imaging. This case contributes to our understanding of ccRCC metastasis, emphasising the necessity for continued clinical vigilance and thorough diagnostic scrutiny, particularly concerning atypical metastatic sites.<\/jats:p>","DOI":"10.1002\/ski2.427","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T07:25:46Z","timestamp":1721373946000},"source":"Crossref","is-referenced-by-count":1,"title":["Clear Cell Renal Cell Carcinoma Micrometastasis: Insights from an Unconventional Cutaneous Presentation"],"prefix":"10.1093","volume":"4","author":[{"given":"Mohammad","family":"Fardos","sequence":"first","affiliation":[{"name":"HCA Healthcare\/USF Morsani College of Medicine GME-HCA Florida Largo Hospital , Largo, Florida ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Kopecky","sequence":"additional","affiliation":[{"name":"HCA Healthcare\/USF Morsani College of Medicine GME-HCA Florida Largo Hospital , Largo, Florida ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Sligh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Morsani College of Medicine University of South Florida\/Bay Pines VA Healthcare System , Bay Pines, Florida ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Browning","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Morsani College of Medicine University of South Florida\/Bay Pines VA Healthcare System , Bay Pines, Florida ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"2025112605522600800_ski2427-bib-0001","doi-asserted-by":"publisher","first-page":"26","DOI":"10.11604\/pamj.2022.42.26.33578","article-title":"Rare metastatic sites of renal cell carcinoma: a case series","volume":"42","author":"Singla","year":"2022","journal-title":"Pan Afr Med J"},{"issue":"2","key":"2025112605522600800_ski2427-bib-0002","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1159\/000508340","article-title":"Skin metastasis of renal cell carcinoma","volume":"13","author":"Mitomi","year":"2020","journal-title":"Case Rep Oncol"},{"issue":"8","key":"2025112605522600800_ski2427-bib-0003","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/bjc.2016.279","article-title":"Detection of micrometastases by flow cytometry in sentinel lymph nodes from patients with renal tumours","volume":"115","author":"Hartana","year":"2016","journal-title":"Br J Cancer"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/5\/ski2.427\/60660771\/skinhd_4_5_e427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/5\/ski2.427\/60660771\/skinhd_4_5_e427.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T10:52:33Z","timestamp":1764154353000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/doi\/10.1002\/ski2.427\/7896855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":3,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,7,19]]},"published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ski2.427","relation":{},"ISSN":["2690-442X"],"issn-type":[{"value":"2690-442X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,7,19]]},"article-number":"ski2.427"}}