{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:07:56Z","timestamp":1764155276119,"version":"3.46.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":140,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This article received no specific grant from any funding agency in the public, commercial or not-for-profit sectors"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Radiation therapy is commonly used to treat various types of malignancies during or after radiation. Approximately 95% percent of patients develop common skin manifestations including dermatitis, atrophy and fibrosis. Rare manifestations, including non-melanoma skin cancers, morphea, cutaneous angiosarcoma and bullous pemphigoid, have been reported post-treatment. The development of lichen planus (LP) from radiation therapy is exceedingly rare, with only 14 previous cases reported. Of these, none were associated with malignant transformation. Malignant transformation from LP is uncommon, with reported cases mainly in oral manifestations of LP at rates of \u223c1%\u20132%. Classic cutaneous manifestations of LP have not been associated with an increased risk of malignancy. We report a unique case of erosive cutaneous LP with malignant transformation in a previously radiated site. Our case highlights a novel cutaneous adverse event to radiation treatment and emphasises the importance of considering erosive LP on the differential when evaluating recalcitrant erosions in a previously radiated area and to monitor closely for transformation to squamous cell carcinoma.<\/jats:p>","DOI":"10.1002\/ski2.443","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T12:39:20Z","timestamp":1724503160000},"source":"Crossref","is-referenced-by-count":0,"title":["Malignant Transformation of Post-Radiation Induced Erosive Lichen Planus to Squamous Cell Carcinoma"],"prefix":"10.1093","volume":"4","author":[{"given":"R. Maxwell","family":"Regester","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin R.","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Sutton","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Arthur","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Nebraska Medical Center , Omaha, Nebraska ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,24]]},"reference":[{"issue":"11","key":"2025112606021378400_ski2443-bib-0001","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8110153","article-title":"Skin manifestations after ionizing radiation exposure: a systematic review","volume":"8","author":"Bennardo","year":"2021","journal-title":"Bioengineering"},{"issue":"2","key":"2025112606021378400_ski2443-bib-0002","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/jdv.18663","article-title":"Evaluation of risk in chronic cutaneous inflammatory conditions for malignant transformation","volume":"37","author":"Ju","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"2025112606021378400_ski2443-bib-0003","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3390\/oral3030024","article-title":"Malignant transformation of oral lichen planus\u2014an umbrella study of systematic reviews","volume":"3","author":"Warnakulasuriya","year":"2023","journal-title":"Oral"},{"issue":"4","key":"2025112606021378400_ski2443-bib-0004","doi-asserted-by":"publisher","first-page":"105","DOI":"10.15570\/actaapa.2017.30","article-title":"Radiation-associated lichen planus: a case report and literature review","volume":"26","author":"Kluger","year":"2017","journal-title":"Acta Dermatovenerol Alpina Pannonica Adriatica"},{"key":"2025112606021378400_ski2443-bib-0005","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jdcr.2017.02.023","article-title":"Isoradiotopic response of lichen planus after radiotherapy of the breast","volume":"3","author":"Hopkins","year":"2017","journal-title":"JAAD Case Rep"},{"issue":"11","key":"2025112606021378400_ski2443-bib-0006","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1159\/000096048","article-title":"Generalized lichen ruber planus\u2013induced by radiotherapy of the breast?","volume":"29","author":"Eichbaum","year":"2006","journal-title":"Oncol Res Treat"},{"journal-title":"Lichen planus arising in radiation therapy treatment sites","author":"Vergilis-Kalner","key":"2025112606021378400_ski2443-bib-0007"},{"issue":"5","key":"2025112606021378400_ski2443-bib-0008","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/j.1365-2230.2007.02449.x","article-title":"Lichen planus induced by radiotherapy","volume":"32","author":"Pretel","year":"2007","journal-title":"Clin Exp Dermatol"},{"journal-title":"Journal of the European Academy of Dermatology and Venereology - Wiley Online Library","article-title":"Multiple erosive lichen planus preceded by solitary lichen planus after combination therapy with nivolumab and radiation - Komori","year":"2017","key":"2025112606021378400_ski2443-bib-0009"},{"key":"2025112606021378400_ski2443-bib-0010","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/205638","article-title":"Squamous cell carcinoma developing in a cutaneous lichen planus lesion: a rare case","volume":"2014","author":"Ghosh","year":"2014","journal-title":"Case Rep Dermatol Med"},{"issue":"3","key":"2025112606021378400_ski2443-bib-0011","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/odi.12885","article-title":"Rate of malignant transformation of oral lichen planus: a systematic review","volume":"25","author":"Giuliani","year":"2019","journal-title":"Oral Dis"}],"container-title":["Skin Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/6\/ski2.443\/61412285\/skinhd_4_6_e443.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/skinhd\/article-pdf\/4\/6\/ski2.443\/61412285\/skinhd_4_6_e443.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:02:19Z","timestamp":1764154939000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/skinhd\/article\/doi\/10.1002\/ski2.443\/7950906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,24]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,8,24]]},"published-print":{"date-parts":[[2024,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ski2.443","relation":{},"ISSN":["2690-442X"],"issn-type":[{"type":"electronic","value":"2690-442X"}],"subject":[],"published-other":{"date-parts":[[2024,12]]},"published":{"date-parts":[[2024,8,24]]},"article-number":"ski2.443"}}