{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:21:53Z","timestamp":1792182113266,"version":"4.4.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":1246,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Michael Piepkorn Endowed Chair in Dermatology Research"},{"name":"Merkel Cell Carcinoma Gift Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with cutaneous T-cell lymphoma (CTCL) often have indolent but symptomatic disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Assessment of the health-related quality of life (HRQoL) of patients with CTCL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Cross-sectional survey study. HRQoL was measured by Skindex-16 and FACT-G.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 372 responses were received; 80 incomplete\/ineligible responses were excluded. A majority of respondents identified as white (87%; 250\/288) and female (67%; 193\/286) with a mean age of 57 \u00b1 14 years. Most patients had early-stage (IA\u2013IIA) (74%; 162\/203) mycosis fungoides (87%; 241\/279). There were 33 (12%; 33\/279) patients with S\u00e9zary syndrome. Mean itch score (visual analogue scale; VAS) was 3.2 \u00b1 2.8, overall; 2.7 \u00b1 2.6 for early, and 4.2 \u00b1 2.9 for advanced disease (p = 0.008). Thirty-eight percent (108\/284) and 24% (69\/284) reported head\/neck and groin\/genital involvement, respectively.<\/jats:p>\n                  <jats:p>Overall HRQoL was 46 \u00b1 27 (Skindex-16) and 71 \u00b1 19 (FACT-G), with worse HRQoL for patients with advanced versus early disease (Skindex-16: 67 vs. 40; p=&amp;lt;0.001, FACT-G: 62 vs. 76; p = 0.001). Predictors of worse HRQoL included head\/neck, hand\/foot or groin\/genital involvement, younger age and spending &amp;gt;15 min daily treating CTCL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Limitations<\/jats:title>\n                  <jats:p>Include anonymous survey methodology, underrepresentation of certain CTCL subtypes and non-white respondents.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with CTCL, particularly those with advanced disease or involvement of the head\/neck, acral or groin\/genital sites, experience significant impact on HRQoL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/ski2.45","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T09:39:01Z","timestamp":1621071541000},"source":"Crossref","is-referenced-by-count":28,"title":["Health-Related Quality of Life in Cutaneous T-Cell Lymphoma: A Cross-Sectional Survey Study"],"prefix":"10.1093","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-5330","authenticated-orcid":false,"given":"M.M.","family":"Shinohara","sequence":"first","affiliation":[{"name":"Division of Dermatology, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.","family":"Mahurin","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Tarabadkar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Emory University , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-4404","authenticated-orcid":false,"given":"D.S.","family":"Hippe","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Lachance","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.T.","family":"Loggers","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, Washington ,","place":["USA"]},{"name":"Division of Hematology\/Oncology, Department of Medicine, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"issue":"1","key":"2025010818033275900_ski245-bib-0001","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jpainsymman.2012.01.012","article-title":"Prevalence and severity of pruritus and quality of life in patients with cutaneous T-cell lymphoma","volume":"45","author":"Wright","year":"2013","journal-title":"J Pain Symptom Manag"},{"issue":"1","key":"2025010818033275900_ski245-bib-0002","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1529-8019.2008.00170.x","article-title":"The psychosocial and occupational impact of chronic skin disease","volume":"21","author":"Hong","year":"2008","journal-title":"Dermatol Ther"},{"issue":"2 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