{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:00:19Z","timestamp":1758891619208,"version":"3.41.2"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":1124,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Central Denmark Region Research Fund"},{"DOI":"10.13039\/501100006286","name":"Aage Bangs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DermaPharm A\/S"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Ichthyosis Vulgaris (IV) is a common genetic skin disease, characterized by dry, scaling skin and itch. Urea cream has been a central part of IV treatment for decades, but only few studies have evaluated the effect of urea compared to basic moisturizers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the treatment effect of 7.5% urea cream compared to a basic moisturizer in patients with IV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Participants (n = 14) were randomized to apply the 7.5% urea cream on one body half and a basic moisturizer on the other during a study period of 4 weeks. Measuring points on participants arms and legs were evaluated at baseline and at endpoint with a patient questionnaire visual assessment scale (VAS), a clinical scoring, and electronic skin hydration analysis to assess the treatment effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>On the arms, no significant differences between the two treatments were found. On the legs, however, the urea treated areas had a significantly higher decrease in SRRC score (0.7 points [95% CI: 1.1\u20130.3, p &amp;lt; 0.005]) and increase in hydration (32.1 \u03bcS [95% CI: 10.9-53.2, p &amp;lt; 0.006]).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Skin hydration improved significantly with both urea and moisturising treatment. On the legs, with most keratinization, urea was superior.<\/jats:p>\n                  <jats:p>Trial registry: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02978209?cond=Ichthyosis+Vulgaris&amp;draw=1&amp;rank=2.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/ski2.65","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T09:45:15Z","timestamp":1631612715000},"source":"Crossref","is-referenced-by-count":4,"title":["Effect of Topical Treatment with 7.5% Urea in Ichthyosis Vulgaris: A Randomized, Controlled, Double Blinded, Split Body Study Evaluating the Effect of Urea Cream Compared to the Vehicle (Moisturizing) Cream"],"prefix":"10.1093","volume":"1","author":[{"given":"I. L. H.","family":"Dorf","sequence":"first","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-4865","authenticated-orcid":false,"given":"M. S.","family":"Lunen","sequence":"additional","affiliation":[{"name":"Department of Intern medicin, Regionshospitalet Silkeborg , Silkeborg ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Koppelhus","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aarhus Universitetshospital Skejby , Aarhus ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,14]]},"reference":[{"key":"2025010818020351000_ski265-bib-0001","first-page":"888","volume-title":"Dermatology Ch. 57","author":"Bolognia","year":"2018"},{"key":"2025010818020351000_ski265-bib-0002","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/jid.2011.393","article-title":"One remarkable molecule: filaggrin","volume":"132","author":"Brown","year":"2012","journal-title":"J Invest Dermatol"},{"key":"2025010818020351000_ski265-bib-0003","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/ddg.12229","article-title":"Nonsyndromic types of ichthyoses - an update","volume":"12","author":"Traupe","year":"2014","journal-title":"J Dtsch Dermatol Ges = Journal of the German Society of Dermatology: JDDG"},{"key":"2025010818020351000_ski265-bib-0004","first-page":"633","article-title":"Urea: A clinically oriented overview from bench to bedside","volume":"15","author":"Friedman","year":"2016","journal-title":"J Drugs Dermatol: JDD"},{"key":"2025010818020351000_ski265-bib-0005","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/jdv.12333","article-title":"Moisturizing treatment of patients with atopic dermatitis and ichtyosis vulgaris improves dry skin but has a modest effect of gene expression regardless FLG genotype","volume":"29","author":"Hoppe","year":"2015","journal-title":"J Eur Acad Dermatol Venerol"},{"key":"2025010818020351000_ski265-bib-0006","doi-asserted-by":"crossref","DOI":"10.5070\/D31911020392","article-title":"Urea: a comprehensive review of the clinical literature","volume":"19","author":"Pan","year":"2013","journal-title":"Dermatol Online J"},{"key":"2025010818020351000_ski265-bib-0007","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000017902","article-title":"Efficacy of urea therapy in children with ichthyosis. 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