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Affect has been shown to be associated with resilience. This study examined the relationship between affect, resilience and fibromyalgia symptom burden in a clinical sample of patients with fibromyalgia. We hypothesized that (a) positive and negative affect would be associated with fibromyalgia symptom burden; (b) resilience would be associated with positive and negative affect; (c) resilience would be associated with fibromyalgia symptom burden; and (d) the connection between resilience and fibromyalgia symptom burden would be mediated by both positive and negative affect. A sample of 858 patients with fibromyalgia completed questionnaires. Mediation modelling revealed statistically significant direct effects of resilience on fibromyalgia symptom burden (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.10, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and statistically significant indirect effects of resilience on fibromyalgia symptom burden through affect (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.36, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), suggesting that both resilience and affect influence fibromyalgia symptom burden. Our results suggest that improving affect through resiliency training could be studied as a modality for improving fibromyalgia symptom burden. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/smi.2555","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T06:02:45Z","timestamp":1388037765000},"page":"299-305","source":"Crossref","is-referenced-by-count":31,"title":["Psychological Resilience, Affective Mechanisms and Symptom Burden in a Tertiary\u2010care Sample of Patients with Fibromyalgia"],"prefix":"10.1002","volume":"31","author":[{"given":"Samantha J.","family":"McAllister","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Vincent","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afton L.","family":"Hassett","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary O.","family":"Whipple","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry H.","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto P.","family":"Benzo","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren L.","family":"Toussaint","sequence":"additional","affiliation":[{"name":"Department of Psychology Luther College  Decorah IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,26]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Amos (Version 7.0)","author":"Arbuckle J. 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