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Sixty\u2010eight healthy subjects randomized to one of three experimental manipulations before undergoing a single PMR session either watched i) a video displaying a neutral expert, ii) a video with a warm expert, or iii) were part of an active control condition. Constrained linear mixed models indicated increased relaxation and decreased stress levels for all participants after the PMR session. The primary outcome was the change of perceived relaxation\/stress from pre to post. Participants with high neuroticism and trait anxiety indicated an augmented PMR's efficacy and increased outcome expectations when watching the warm expert video compared to the control group or the less warm expert. Brief videos displaying an expert aiming to optimise outcome expectations regarding a brief stress\u2010reducing psychological intervention may boost or decrease an intervention's efficacy. Effects may depend on the viewer's personality and the (video) expert's communication style.<\/jats:p><jats:p>Trial Registration: The study protocol was approved by the local Ethics Committee of the University of Marburg, Germany. This study was registered at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link> (NCT03330431).<\/jats:p>","DOI":"10.1002\/smi.3128","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T02:13:32Z","timestamp":1642558412000},"page":"722-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optimising the efficacy of a stress\u2010reducing psychological intervention using placebo mechanisms: A randomized controlled trial"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-0303","authenticated-orcid":false,"given":"Stefan","family":"Salzmann","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy Philipps University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Wilhelm","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy Philipps University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schindler","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology and Systems Neuroscience and Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience University of Muenster  Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Rief","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy Philipps University of Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Euteneuer","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy Philipps University of Marburg  Marburg Germany"},{"name":"Clinical Psychology and Psychotherapy Medical School Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742\u20105573\u20108\u20101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/eip.12212"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1525\/9780520313514-018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1024\/\/0170\u20101789.22.3.155"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1995.tb02031.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022\u2010006X.61.6.1059"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2015.1053454"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102702.2008.02773.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.106"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102016\u2010013096"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.20754"},{"key":"e_1_2_9_13_1","first-page":"17","article-title":"The five\u2010factor model of personality and its relevance to personality disordersPersonality and Personality Disorder","volume":"76","author":"Costa P. 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