{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:27:45Z","timestamp":1787164065500,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stress and Health"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Maternal stress during pregnancy is associated with differential DNA methylation in offspring and disrupted cortisol secretion. This study aimed to determine methylation signatures of cortisol levels in children, and whether associations differ based on maternal post\u2010traumatic stress disorder (PTSD). Blood epigenome\u2010wide methylation and fasting cortisol levels were measured in 118 offspring of mothers recruited from the Kosovo Rehabilitation Centre for Torture Victims. Mothers underwent clinically administered assessment for PTSD using Diagnostic and Statistical Manual of Mental Disorders. Correlations between offspring methylation and cortisol levels were examined using epigenome\u2010wide analysis, adjusting for covariates. Subsequent analysis focussed on a priori selected genes involved in the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis stress signalling. Methylation at four sites were correlated with cortisol levels (cg15321696,\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.33, cg18105800,\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0+0.33, cg00986889,\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.25, and cg15920527,\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a0\u22120.27). In adjusted multivariable regression, when stratifying based on prenatal PTSD status, significant associations were only found for children born to mothers with prenatal PTSD (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Several sites within HPA axis genes were also associated with cortisol levels in the maternal PTSD group specifically. There is evidence that methylation is associated with cortisol levels, particularly in offspring born to mothers with prenatal PTSD. However, larger studies need to be carried out to independently validate these findings.\n                  <\/jats:p>","DOI":"10.1002\/smi.3131","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T11:24:50Z","timestamp":1643973890000},"page":"755-766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["DNA methylation in blood cells is associated with cortisol levels in offspring of mothers who had prenatal post\u2010traumatic stress disorder"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3515-0557","authenticated-orcid":false,"given":"Peter Daniel","family":"Fransquet","sequence":"first","affiliation":[{"name":"School of Public Health and Preventive Medicine Biological Neuropsychiatry and Dementia Unit Monash University  Melbourne Victoria 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Rehabilitation Center for Torture Victims  Pristina Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvi Izeti","family":"\u00c7arkaxhiu","sequence":"additional","affiliation":[{"name":"Kosovo Rehabilitation Center for Torture Victims  Pristina Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafina","family":"Arifaj","sequence":"additional","affiliation":[{"name":"Kosovo Rehabilitation Center for Torture Victims  Pristina Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vjosa Devaja","family":"Xhemaili","sequence":"additional","affiliation":[{"name":"Kosovo Rehabilitation Center for Torture Victims  Pristina Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimoza","family":"Salihu","sequence":"additional","affiliation":[{"name":"Kosovo Rehabilitation Center for Torture Victims  Pristina Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazmie Abullahu","family":"Leku","sequence":"additional","affiliation":[{"name":"Kosovo Rehabilitation Center for Torture Victims  Pristina Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7039-6325","authenticated-orcid":false,"given":"Joanne","family":"Ryan","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Biological Neuropsychiatry and Dementia Unit Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.86.5.726"},{"key":"e_1_2_9_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Publishing 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