{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:45:29Z","timestamp":1790207129474,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stress and Health"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to determine whether ascorbic acid (AA) supplementation can lower plasma levels of Cortisol and dehydroepiandrosterone\u2010sulphate (DHEA\u2010S) in patients diagnosed with functional hypercortisolemia due to unspecified chronic stress. Study includes data from 69 female with elevations in the cortisol and DHEA\u2010S levels. Duration of follow\u2010up was 2\u00a0months. Patients were divided into 3 groups. Group I included patients 23 with elevated cortisol, Group II\u2014patients 24 with elevated levels of both hormones, Group III\u2010 patients 22 with normal cortisol and increased DHEA\u2010S. Each group was randomly divided into two subgroups. The first subgroup was prescribed 1000\u00a0mg daily oral dose of AA. The diet of the second subgroup were left unaltered. All patients have their hormones levels re\u2010examined 2\u00a0months later. After 2\u00a0months of AA supplementation the mean levels of elevated plasma cortisol and DHEA\u2010S decreased. In Group I the level of cortisol fell from 780\u00a0\u00b1\u00a057\u2013446\u00a0\u00b1\u00a026\u00a0nmol\/L, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.000065 in Group II from 657\u00a0\u00b1\u00a047\u2013515\u00a0\u00b1\u00a029\u00a0nmol\/L, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005. The elevated levels of DHEA\u2010S have also declined in patients from AA\u2010treated subgroups (from 13.9\u00a0\u00b1\u00a01.6\u20139.9\u00a0\u00b1\u00a01.2, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0007 in Group II, and from 12.8\u00a0\u00b1\u00a01.0\u20137.8\u00a0\u00b1\u00a01.4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003 in Group III). In untreated subgroups changes in hormone levels were insignificant. The study shows that female patients with functional hypercortisolemia or elevated levels of DHEA\u2010S can be treated with AA to bring level of these hormones closer to a normal range.<\/jats:p>","DOI":"10.1002\/smi.3347","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:53:29Z","timestamp":1701132809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vitamin C supplementation alleviates hypercortisolemia caused by chronic stress"],"prefix":"10.1002","volume":"40","author":[{"given":"Narine","family":"Beglaryan","sequence":"first","affiliation":[{"name":"Astghik Medical Center  Yerevan Armenia"},{"name":"Department of Endocrinology and Endocrine Surgery Yerevan State Medical University Named after Mkhitar Heratsi  Yerevan Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-9070","authenticated-orcid":false,"given":"Gagik","family":"Hakobyan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Yerevan State Medical University after M. Heratsi  Yerevan Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Nazaretyan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yerevan State Medical University Named after Mkhitar Heratsi  Yerevan Armenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.1.191"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20102275(20)41269\u20106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02\u20101167fje"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29306"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/117.6.1108"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.60.367"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2022.685\u2010693"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005\u20102760(70)90179\u20107"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20108981(75)90250\u20108"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo\u201066\u20101\u2010144"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2020.3280"},{"issue":"1","key":"e_1_2_11_13_1","first-page":"9","article-title":"Ascorbic acid transport by isolated bovine adrenal medullary cells","volume":"32","author":"Minakuchi K.","year":"1985","journal-title":"Tokushima Journal of Experimental Medicine"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdn076"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.1.145"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1081\/erc\u2010200044126"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102001\u201011364"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo\u201040\u20104\u2010265"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27016"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.4667.1383"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010013\u20100112\u2010y"}],"container-title":["Stress and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smi.3347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:45:45Z","timestamp":1748432745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smi.3347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/smi.3347"],"URL":"https:\/\/doi.org\/10.1002\/smi.3347","archive":["Portico"],"relation":{},"ISSN":["1532-3005","1532-2998"],"issn-type":[{"value":"1532-3005","type":"print"},{"value":"1532-2998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]},"assertion":[{"value":"2023-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3347"}}