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In this review, we discuss the field of mind\u2010body medicine, which focuses on improving our understanding of the mechanisms underlying this response and developing interventions that might be used to limit the effects of chronic stress. We review the findings of past and current research in this field that has focused on the impact of psychological, emotional, and behavioural factors, including love, social connectedness, and happiness on human health and the amelioration of pain as well as other signs and symptoms of disease. While these studies have not yet led to confirmed, quantifiable conclusions, the overall weight of evidence suggests that happiness (defined as a personal sense of well\u2010being) may be directly associated with improved health parameters and reductions in debilitating symptoms. Collectively, these findings suggest that interventions designed to promote stress mitigation, notably those that encourage social activity, may lead to significant improvements in human health.<\/jats:p>","DOI":"10.1002\/smi.3387","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T17:49:30Z","timestamp":1709660970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The foundations of mind\u2010body medicine: Love, good relationships, and happiness modulate stress and promote health"],"prefix":"10.1002","volume":"40","author":[{"given":"Tobias","family":"Esch","sequence":"first","affiliation":[{"name":"Institute for Integrative Health Care and Health Promotion Witten\/Herdecke University  Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George B.","family":"Stefano","sequence":"additional","affiliation":[{"name":"Institute for Integrative Health Care and Health Promotion Witten\/Herdecke University  Witten Germany"},{"name":"First Faculty of Medicine Department of Psychiatry of the First Faculty of Medicine and General Teaching Hospital Charles University in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-5839","authenticated-orcid":false,"given":"Maren M.","family":"Michaelsen","sequence":"additional","affiliation":[{"name":"Institute for Integrative Health Care and Health Promotion Witten\/Herdecke University  Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.05.018"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010021\u201001590\u20104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.1.30"},{"key":"e_1_2_10_5_1","volume-title":"Health, stress and coping","author":"Antonovsky A.","year":"1979"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/heapro\/11.1.11"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090198110376352"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"38","article-title":"The effect of mirthful laughter on stress and natural killer cell activity","volume":"9","author":"Bennett M. 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