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The study sample consisted of 97 women divided into four groups: 37 healthy women (HW), 21 with systemic lupus erythematosus (SLE), 21 with Sj\u00f6gren's syndrome (SS), and 18 with systemic sclerosis (SSc). After being exposed to a stress task, participants' skin conductance and salivary cortisol levels were measured in order to assess their response to psychological stress. Diurnal cortisol concentrations were assessed by measuring salivary cortisol in samples collected five times over one day. In addition, self\u2010administered questionnaires were used to assess psychological variables. A time\u00a0\u00d7\u00a0group interaction effect was found (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) in salivary cortisol secretion in response to stressful challenge. The healthy group presented normal activation, the SS and SLE groups showed no activation, and the SSc group presented a similar activation pattern to the HW group, except at the time of recovery. Total cortisol production (AUCg) was higher in the SSc group than in the HW group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Differences were also observed in the cortisol AUCg collected over one day between healthy women and patients with SLE (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) as well as with SSc (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001): women with SLE and SSc presented higher total hormone production than healthy women. Patients with autoimmune disease present a different HPA axis response, which may contribute to the harmful effects of stress in these diseases.<\/jats:p>","DOI":"10.1002\/smi.3392","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T07:14:55Z","timestamp":1709882095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does stress response axis activation differ between patients with autoimmune disease and healthy people?"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4388-5131","authenticated-orcid":false,"given":"Eva","family":"Montero\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Evolutionary Psychology University of Granada  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8201-8906","authenticated-orcid":false,"given":"Mar\u00eda Isabel","family":"Peralta\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Personality, Evaluation, and Psychological Treatment University of Granada  Granada Spain"},{"name":"Mind, Brain and Behavior Research Center (CIMCYC)  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2325-0937","authenticated-orcid":false,"given":"Norberto","family":"Ortego\u2010Centeno","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Granada  Granada Spain"},{"name":"Systemic Autoimmune Diseases Unit San Cecilio Clinical Hospital  Granada Spain"},{"name":"Biohealth Research Institute (IBS)  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4095-7379","authenticated-orcid":false,"given":"Jos\u00e9 Mario","family":"Sabio","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune Disease Unit Internal Medicine Service Virgen de las Nieves University Hospital  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-0087","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Callejas\u2010Rubio","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune Diseases Unit San Cecilio Clinical Hospital  Granada Spain"},{"name":"Biohealth Research Institute (IBS)  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Navarrete\u2010Navarrete","sequence":"additional","affiliation":[{"name":"Systemic Autoimmune Disease Unit Internal Medicine Service Virgen de las Nieves University Hospital  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2913-1410","authenticated-orcid":false,"given":"M. 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