{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:29:40Z","timestamp":1788496180571,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stress and Health"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>It would be highly valuable to possess a tool for evaluating disease progression and identifying patients at risk of experiencing a more severe clinical course and potentially worse outcomes. The concept of allostatic load, which represents the overall strain on the body from repeated stress responses, has been recognized as a precursor to the development of chronic illnesses. It functions as a cumulative measure of the body's capacity to adapt to stress. Numerous studies have demonstrated that elevated allostatic load levels are associated with various negative health outcomes, both physical and mental, and are more predictive of mortality than individual biomarkers. Leveraging the unique circumstances presented by the COVID\u201019 pandemic, we evaluated different clinical and laboratory parameters in hospitalised COVID\u201019 patients to assess allostatic load. Our results indicated that allostatic load acts as a strong predictor of prolonged hospitalisation, increased ICU days, and mortality. This highlights its efficacy as a precise gauge of biological dysregulation linked to the response to COVID\u201019 during disease progression. Allostatic load is easily obtainable and provides an early, cost\u2010effective indication of disease prognosis. Additionally, it has the potential to forecast the necessity for ICU admission. As a result, this parameter, indicative of the comprehensive physiological disruption in response to stress, emerges as a promising prognostic marker for hospitalised patients, extending beyond COVID\u201019.<\/jats:p>","DOI":"10.1002\/smi.3527","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T01:10:24Z","timestamp":1736471424000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Allostatic Load as a Short\u2010Term Prognostic and Predictive Marker"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1615-9345","authenticated-orcid":false,"given":"Ana M. G\u00f3mez","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"Internal Medicine Unit Hospital Universitario HM Madrid  Madrid Spain"},{"name":"Facultad HM de Ciencias de la Salud de la Universidad Camilo Jos\u00e9 Cela  Villafranca del Castillo Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1006-0958","authenticated-orcid":false,"given":"Angel Jes\u00fas","family":"Arias Arias","sequence":"additional","affiliation":[{"name":"Facultad HM de Ciencias de la Salud de la Universidad Camilo Jos\u00e9 Cela  Villafranca del Castillo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco L\u00f3pez","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Facultad HM de Ciencias de la Salud de la Universidad Camilo Jos\u00e9 Cela  Villafranca del Castillo Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Garc\u00eda\u2010Rico","sequence":"additional","affiliation":[{"name":"Facultad HM de Ciencias de la Salud de la Universidad Camilo Jos\u00e9 Cela  Villafranca del Castillo Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria HM Hospitales  Madrid Spain"},{"name":"Medical Oncology Unit Hospital Universitario HM Torrelodones  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5937\/jomb0\u201027554"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201005952\u20104"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1099800412455688"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491012500608"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010057136"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2019.04.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2022.111050"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010018\u20100364\u20101"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137244"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523\u2010024\u201000654\u20102"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2020.1783198"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2141"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40615\u2010016\u20100246\u20108"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2018.03.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2022.105726"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e318157cba6"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.02.27.20027524"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510696"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.07.024"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab187"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010030\u201059261\u20105_25"},{"key":"e_1_2_11_23_1","first-page":"3","volume-title":"Biological Markers in Epidemiology","author":"Hulka B. 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