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Studies have shown that coping strategies and sex modulate subjective stress, although their effects on stress hormones have been overlooked. In addition, it remains unknown whether sex and coping interact to predict these stress metrics during long\u2010term stressful events. To examine the impact of coping strategies, sex, and their interaction on subjective and physiological indicators of stress during the year following the arrival of the COVID\u201019 virus. Coping strategies were assessed using the Brief COPE questionnaire in May 2020. Stress symptoms were assessed as a subjective indicator of stress every 3\u00a0months (June 2020 to March 2021) with the Perceived Stress Scale questionnaire in 155 participants (49 men). Of these individuals, 111 provided a 6\u2010cm hair sample in June 2020 to estimate cortisol levels as a physiological indicator of stress before and during the first lockdown. A factor analysis identified three clusters of coping strategies: positive\u2010oriented, avoidance\u2010oriented, and social support. For subjective stress, a linear\u2010mixed model showed that women reported more stress than men. Positive\u2010oriented and avoidance\u2010oriented strategies were associated with less and more stress, respectively. An interaction between sex and coping strategies indicated a positive relationship between social support and perceived stress levels in men. However, among men and women who used this strategy infrequently, women reported higher stress levels than men. For physiological stress, a regression revealed that women had greater cortisol secretion in response to the pandemic. These findings suggest that coping and sex modulate subjective stress, whereas sex influences physiological stress.<\/jats:p>","DOI":"10.1002\/smi.70012","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T06:30:26Z","timestamp":1738737026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Coping Strategies on Perceived Stress and Hair Cortisol Levels During the COVID\u201019 Pandemic According to Sex"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-1915","authenticated-orcid":false,"given":"Maryse","family":"Arcand","sequence":"first","affiliation":[{"name":"Centre de recherche de l\u2019Institut universitaire en sant\u00e9 mentale de Montr\u00e9al  Montreal Canada"},{"name":"Department of Psychiatry and Addiction Universit\u00e9 de Montr\u00e9al  Montr\u00e9al 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