{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:39:37Z","timestamp":1761763177415,"version":"build-2065373602"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001747","name":"Hong Kong Baptist University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stress and Health"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      This study aimed to characterize the changes in sleep and mood and assess the safety of a Chinese herbal formula Depression (DEP)\u20102306 in adults with a depressive episode with insufficient symptoms (DEIS). Additionally, it explored the factors associated with the outcome remission with significant improvement. Between June 2023 and January 2024, 67 DEIS patients were administered daily DEP\u20102306 over 4 weeks. The main outcomes included depression severity (Patient Health Questionnaire\u20109 [PHQ\u20109] and Hamilton depression rating scale [HAMD\u201017]), anxiety severity (General Anxiety Disorder\u20107 [GAD\u20107]), and sleep quality (Pittsburgh Sleep Quality Index [PSQI]). A linear mixed model was used to analyse the score changes, and logistic regression was used to identify factors associated with the outcome remission with significant improvement, which was defined as a PHQ\u20109 score \u2264\u00a04 and a \u2265\u00a050% reduction from baseline. The results demonstrated that there were significant reductions in PHQ\u20109 scores from 11.8 to 6.7 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01, Cohen's\n                      <jats:italic>D<\/jats:italic>\n                      \u00a0=\u00a01.55), GAD\u20107 scores from 10.6 to 6.0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01, Cohen's\n                      <jats:italic>D<\/jats:italic>\n                      \u00a0=\u00a01.03), and PSQI scores from 10.3 to 7.9 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01, Cohen's\n                      <jats:italic>D<\/jats:italic>\n                      \u00a0=\u00a00.76). 38.6% (22 out of 57) of the participants achieved remission with significant improvement. Further analyses indicated that the presence of attitudinal barriers towards conventional psychological\/psychiatric treatments and lower sleep disturbance scores at baseline increased the likelihood of achieving remission with significant improvement. The 4\u2010week DEP\u20102306 intervention significantly alleviated symptoms of depression and anxiety, and improved sleep quality, suggesting a potential transdiagnostic outcome in DEIS. It was particularly responsive in individuals with attitudinal barriers and milder sleep disturbances at baseline.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      This real\u2010world study was retrospectively registered with the International Traditional Medicine Clinical Trial Registry (ITMCTR2025000835) on April 24, 2025.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/smi.70104","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T05:43:41Z","timestamp":1758347021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transdiagnostic Effects of a Chinese Herbal Formula DEP\u20102306 on Improving Sleep and Mood in Adults With Depressive Episode With Insufficient Symptoms: A Real\u2010World Study"],"prefix":"10.1002","volume":"41","author":[{"given":"Hiu To","family":"Tang","sequence":"first","affiliation":[{"name":"Vincent V.C. Woo Chinese Medicine Clinical Research Institute School of Chinese Medicine Hong Kong Baptist University  Hong Kong SAR China"},{"name":"School of Chinese Medicine Hong Kong Baptist University  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zong","sequence":"additional","affiliation":[{"name":"Department of Neurology West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoming","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine Hong Kong Baptist University  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Wang","sequence":"additional","affiliation":[{"name":"Sleep Research Clinic and Laboratory Department of Psychology The University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Yeung","sequence":"additional","affiliation":[{"name":"Depression Clinical and Research Program Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1811-3682","authenticated-orcid":false,"given":"Danny J.","family":"Yu","sequence":"additional","affiliation":[{"name":"Vincent V.C. Woo Chinese Medicine Clinical Research Institute School of Chinese Medicine Hong Kong Baptist University  Hong Kong SAR China"},{"name":"School of Chinese Medicine Hong Kong Baptist University  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-1958","authenticated-orcid":false,"given":"Zhaoxiang","family":"Bian","sequence":"additional","affiliation":[{"name":"Vincent V.C. Woo Chinese Medicine Clinical Research Institute School of Chinese Medicine Hong Kong Baptist University  Hong Kong SAR China"},{"name":"School of Chinese Medicine Hong Kong Baptist University  Hong Kong SAR China"},{"name":"Centre for Chinese Herbal Medicine Drug Development Limited Hong Kong Baptist University  Hong Kong SAR China"},{"name":"The Chinese Medicine Hospital of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association.2013. \u201cDiagnostic and Statistical Manual of Mental Disorders.\u201d21 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