{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:21:43Z","timestamp":1787808103783,"version":"build-2784847793"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/25423\u20108"],"award-info":[{"award-number":["2019\/25423\u20108"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/13092\u20107"],"award-info":[{"award-number":["2021\/13092\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stress and Health"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alcohol Use Disorder (AUD) is a multifactorial condition shaped by genetic predispositions and neurophysiological, behavioural, and environmental factors. Chronic stress and trauma are key drivers of harmful alcohol use. This study aimed to investigate, in a Brazilian admixed population, the associations and interactions between genetic variants related to the CRFergic, noradrenergic, and glucocorticoid receptor systems and exposure to childhood and adulthood stressors, as well as perceived stress, in individuals with and without AUD. We evaluated 227 inpatients with AUD and 174 controls. Alcohol involvement was assessed using the AUDIT and IDS\u201042. Childhood trauma, adult\u2010life stressors, and perceived stress were measured using the CTQ, LES, and PSS, respectively. Genetic variants were characterised using next\u2010generation sequencing. Individuals with AUD showed more severe childhood trauma, more adverse adult\u2010life experiences, and higher perceived stress. Two\n                    <jats:italic>CRHR2<\/jats:italic>\n                    variants were significantly associated with AUD after correction for multiple testing (rs8175360 increasing risk; rs41417745 decreasing risk). Stress\u2010related genetic variation, particularly in\n                    <jats:italic>CRHR2<\/jats:italic>\n                    , was associated with AUD diagnosis in interaction with environmental stressors across the lifespan. These findings highlight the importance of integrating genetic and environmental factors to better understand the heterogeneity of AUD and may inform future approaches to personalised prevention and intervention strategies.\n                  <\/jats:p>","DOI":"10.1002\/smi.70193","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:15:11Z","timestamp":1782818111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Stress\u2010Related Genetic Polymorphisms and Stressful Life Events With Alcohol Use Disorder in a Brazilian Population"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4806-3548","authenticated-orcid":false,"given":"Isabel Cristina","family":"C\u00e9spedes","sequence":"first","affiliation":[{"name":"Department of Morphology and Genetics Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Morphology and Genetics Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Kiyomi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Morphology and Genetics Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-9199","authenticated-orcid":false,"given":"Diego Robles","family":"Mazzotti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kansas Medical Center (KUMC)  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2580-6775","authenticated-orcid":false,"given":"Tatiana","family":"Wscieklica","sequence":"additional","affiliation":[{"name":"Department of Morphology and Genetics Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-9693","authenticated-orcid":false,"given":"Jos\u00e9 Carlos Fernandes","family":"Galdur\u00f3z","sequence":"additional","affiliation":[{"name":"Department of Psychobiology Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2165-0761","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Varela","sequence":"additional","affiliation":[{"name":"Department of Biophysics Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Bosco","family":"Pesquero","sequence":"additional","affiliation":[{"name":"Department of Biophysics Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-7569","authenticated-orcid":false,"given":"La\u00eds da Silva","family":"Pereira\u2010Rufino","sequence":"additional","affiliation":[{"name":"Department of Morphology and Genetics Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia Oliveira","family":"Souza\u2010Formigoni","sequence":"additional","affiliation":[{"name":"Department of Psychobiology Escola Paulista de Medicina Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.09.009"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.26502\/jppd.2572\u2010519X0260"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2011_142"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.04.028"},{"key":"e_1_2_9_6_1","unstructured":"Bernstein D. 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