{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:54:02Z","timestamp":1791968042696,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["465482\/2014\u20107"],"award-info":[{"award-number":["465482\/2014\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Stress and Health"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Women with recurrent pregnancy loss (RPL) exhibit high levels of depression, anxiety, and stress, which negatively impact their quality of life. This randomized clinical trial evaluated the effects of an eight\u2010week online Mindfulness\u2010Based Intervention (MBI), with weekly one\u2010hour sessions, on psychological and biological markers of stress in 35 women with RPL. Participants were randomly assigned to either the MBI or standard care (control group) and assessed before and after the intervention through salivary biomarkers (cortisol, alpha\u2010amylase, and Immunoglobulin A\u2014IgA) and the validated questionnaires Depression, Anxiety and Stress Scale\u201021 (DASS\u201021) and Psychological General Well\u2010Being Index (PGWB\u2010I). No significant time\u00a0\u00d7\u00a0group interactions were observed for salivary biomarkers, including cortisol (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.672), alpha\u2010amylase (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.342), and IgA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.148). Participants in the MBI group showed significant reductions in total DASS\u201021 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.018), depression (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.026), and stress (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.015) scores, whereas anxiety did not differ significantly between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.121). They also showed robust improvements in overall well\u2010being (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and multiple PGWB\u2010I domains. These findings suggest that MBI may improve self\u2010reported psychological well\u2010being in women with RPL; however, as no significant effects were observed in the primary biomarker outcomes, these secondary psychological findings should be considered exploratory and hypothesis\u2010generating.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/ensaiosclinicos.gov.br\/rg\/RBR-4xc76cr\">https:\/\/ensaiosclinicos.gov.br\/rg\/RBR\u20104xc76cr<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/smi.70228","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:34:21Z","timestamp":1791966861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Mindfulness Therapy on Stress Biomarkers and Psychological Symptoms in Women With Recurrent Pregnancy Loss: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8525-0575","authenticated-orcid":false,"given":"Elaine C.\u00a0F.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8107-4540","authenticated-orcid":false,"given":"Sara P.\u00a0C.","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Department of Oncology Georgetown University Medical Center  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-8686","authenticated-orcid":false,"given":"Enrrico","family":"Bloise","sequence":"additional","affiliation":[{"name":"Department of Morphology Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-7472","authenticated-orcid":false,"given":"Fernando M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.13937"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/01674820701687521"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000328"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865\u2010007\u20109130\u20107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","DOI":"10.1201\/b17855","volume-title":"Recurrent Pregnancy Loss: Causes, Controversies, and Treatment","author":"Carp H. 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