{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:22:54Z","timestamp":1790400174525,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T00:00:00Z","timestamp":1361923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small"],"published-print":{"date-parts":[[2013,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Development of portable biosensors has broad applications in environmental monitoring, clinical diagnosis, public health, and homeland security. There is an unmet need for pathogen detection at the point\u2010of\u2010care (POC) using a fast, sensitive, inexpensive, and easy\u2010to\u2010use method that does not require complex infrastructure and well\u2010trained technicians. For instance, detection of Human Immunodeficiency Virus (HIV\u20101) at acute infection stage has been challenging, since current antibody\u2010based POC technologies are not effective due to low concentration of antibodies. In this study, we demonstrated for the first time a label\u2010free electrical sensing method that can detect lysed viruses, i.e. viral nano\u2010lysate, through impedance analysis, offering an alternative technology to the antibody\u2010based methods such as dipsticks and Enzyme\u2010linked Immunosorbent Assay (ELISA). The presented method is a broadly applicable platform technology that can potentially be adapted to detect multiple pathogens utilizing impedance spectroscopy for other infectious diseases including herpes, influenza, hepatitis, pox, malaria, and tuberculosis. The presented method offers a rapid and portable tool that can be used as a detection technology at the POC in resource\u2010constrained settings, as well as hospital and primary care settings.<\/jats:p>","DOI":"10.1002\/smll.201202195","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T14:12:03Z","timestamp":1361974323000},"page":"2553-2563","source":"Crossref","is-referenced-by-count":88,"title":["Acute On\u2010Chip HIV Detection Through Label\u2010Free Electrical Sensing of Viral Nano\u2010Lysate"],"prefix":"10.1002","volume":"9","author":[{"given":"Hadi","family":"Shafiee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muntasir","family":"Jahangir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Inci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShuQi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remington B. 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