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In this study, HER\u20102 targeted magnetic iron oxide nanoparticles (IONPs) are developed by conjugating a high affinity and small size HER\u20102 affibody that is labeled with a unique near infrared dye (NIR\u2010830) to the nanoparticles. Using a clinically relevant orthotopic human ovarian tumor xenograft model, it is shown that HER\u20102 targeted IONPs are selectively delivered into both primary and disseminated ovarian tumors, enabling non\u2010invasive optical and MR imaging of the tumors as small as 1 mm in the peritoneal cavity. It is determined that HER\u20102 targeted delivery of the IONPs is essential for specific and sensitive imaging of the HER\u20102 positive tumor since we are unable to detect the imaging signal in the tumors following systemic delivery of non\u2010targeted IONPs into the mice bearing HER\u20102 positive SKOV3 tumors. Furthermore, imaging signals and the IONPs are not detected in HER\u20102 low expressing OVCAR3 tumors after systemic delivery of HER\u20102 targeted\u2010IONPs. Since HER\u20102 is expressed in a high percentage of ovarian cancers, the HER\u20102 targeted dual imaging modality IONPs have potential for the development of novel targeted imaging and therapeutic nanoparticles for ovarian cancer detection, targeted drug delivery, and image\u2010guided therapy and surgery.<\/jats:p>","DOI":"10.1002\/smll.201301593","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T07:33:57Z","timestamp":1377588837000},"page":"544-555","source":"Crossref","is-referenced-by-count":65,"title":["Active Targeting Using HER\u20102\u2010Affibody\u2010Conjugated Nanoparticles Enabled Sensitive and Specific Imaging of Orthotopic HER\u20102 Positive Ovarian Tumors"],"prefix":"10.1002","volume":"10","author":[{"given":"Minati","family":"Satpathy","sequence":"first","affiliation":[{"name":"Emory University School of Medicine  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Wang","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Zielinski","sequence":"additional","affiliation":[{"name":"Anderson Cancer Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Qian","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Lipowska","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Capala","sequence":"additional","affiliation":[{"name":"Radiation Oncology National Institutes of Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gee Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"Ocean Nanotech, LLC  Springdale AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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