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In this study, for the first time, the in vivo spatiotemporal disposition of recently developed mercaptosuccinic acid (MSA)\u2010capped cadmium telluride\/cadmium sulfide (CdTe\/CdS) quantum dots (QDs) is explored in rat liver using multiphoton microscopy (MPM) coupled with fluorescence lifetime imaging (FLIM), with subcellular resolution (\u223c1 \u03bcm). With high fluorescence efficiency and largely improved stability in the biological environment, these QDs show a distinct distribution pattern in the liver compared to organic dyes, rhodamine 123 and fluorescein. After intravenous injection, fluorescent molecules are taken up by hepatocytes and excreted into the bile, while negatively charged QDs are retained in the sinusoids and selectively taken up by sinusoidal cells (Kupffer cells and liver sinusoidal endothelial cells), but not by hepatocytes within 3 h. The results could help design NPs targeting the specific types of liver cells and choose the fluorescent markers for appropriate cellular imaging.<\/jats:p>","DOI":"10.1002\/smll.201402698","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T04:16:31Z","timestamp":1418616991000},"page":"1711-1720","source":"Crossref","is-referenced-by-count":37,"title":["Intravital Multiphoton Imaging of the Selective Uptake of Water\u2010Dispersible Quantum Dots into Sinusoidal Liver Cells"],"prefix":"10.1002","volume":"11","author":[{"given":"Xiaowen","family":"Liang","sequence":"first","affiliation":[{"name":"Therapeutics Research Centre, School of Medicine The University of Queensland, Translational Research Institute  37 Kent Street Woolloongabba QLD 4102 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Grice","sequence":"additional","affiliation":[{"name":"Therapeutics Research Centre, School of Medicine The University of Queensland, Translational Research Institute  37 Kent Street Woolloongabba QLD 4102 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Therapeutics Research Centre, School of Medicine The University of Queensland, Translational Research Institute  37 Kent Street Woolloongabba QLD 4102 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Liu","sequence":"additional","affiliation":[{"name":"Therapeutics Research Centre, School of Medicine The University of Queensland, Translational Research Institute  37 Kent Street Woolloongabba QLD 4102 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Washington Y.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Therapeutics Research Centre, School of Medicine The University of Queensland, Translational Research Institute  37 Kent Street Woolloongabba QLD 4102 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Radiation Medicine and Radiation Protection Soochow University  Suzhou 215123 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell H. 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