{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:56:43Z","timestamp":1770893803359,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Nuclear magnetic resonance (NMR) spectroscopy is a physical marvel in which electromagnetic radiation is charged and discharged by nuclei in a magnetic field. In conventional NMR, the specific nuclei resonance frequency depends on the strength of the magnetic field and the magnetic properties of the isotope of the atoms. NMR is routinely utilized in clinical tests by converting nuclear spectroscopy in magnetic resonance imaging (MRI) and providing 3D, noninvasive biological imaging. While this technique has revolutionized biomedical science, measuring the magnetic resonance spectrum of single biomolecules is still an intangible aspiration, due to MRI resolution being limited to tens of micrometers. MRI and NMR have, however, recently greatly advanced, with many breakthroughs in nano\u2010NMR and nano\u2010MRI spurred by using spin sensors based on an atomic impurities in diamond. These techniques rely on magnetic dipole\u2013dipole interactions rather than inductive detection. Here, novel nano\u2010MRI methods based on nitrogen vacancy centers in diamond are highlighted, that provide a solution to the imaging of single biomolecules with nanoscale resolution in\u2010vivo and in ambient conditions.<\/jats:p>","DOI":"10.1002\/smll.201500764","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T16:52:15Z","timestamp":1435251135000},"page":"4229-4236","source":"Crossref","is-referenced-by-count":15,"title":["Towards Single Biomolecule Imaging via Optical Nanoscale Magnetic Resonance Imaging"],"prefix":"10.1002","volume":"11","author":[{"given":"Alberto","family":"Boretti","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering (MAE) Benjamin M. Statler College of Engineering and Mineral Resources West Virginia University (WVU)  PO Box 6106, 325 Engineering Sciences Building Morgantown WV 26506 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Rosa","sequence":"additional","affiliation":[{"name":"Swinburne University of Technology Centre for Micro\u2010Photonics (H74)  PO Box 218 Hawthorn VIC 3122 Australia"},{"name":"University of Parma Department of Information Engineering  Viale G.P. Usberti 181\/A 43124 Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Castelletto","sequence":"additional","affiliation":[{"name":"Swinburne University of Technology Centre for Micro\u2010Photonics (H74)  PO Box 218 Hawthorn VIC 3122 Australia"},{"name":"School of Aerospace Mechanical and Manufacturing Engineering RMIT University  PO Box 71 Bundoora VIC 3083 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/65\/10\/203"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1051\/jphysrad:01950001106025500"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.30.158"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7539550"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspa.1976.0039"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.74.104303"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn9003617"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2420"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2771"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-040513-103659"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/77\/5\/056503"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat3805"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.2943282"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2420"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphys1075"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.94.630"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2014.313"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3507884"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.112.160802"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12072"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nphys2543"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.152"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231540"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231675"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5703"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2014.288"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2253"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2014.299"},{"key":"e_1_2_5_29_1","first-page":"011001","volume":"5","author":"Ajoy A.","year":"2015","journal-title":"Phys. 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