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Specifically, as neuroblastoma occurs in infancy and childhood, targeted delivery may be critical to reduce the side effects that can occur with conventional approaches, as well as to achieve precise diagnosis and efficient therapy. Thus, biocompatible poly(<jats:sc>d<\/jats:sc>,<jats:sc>l<\/jats:sc>\u2010lactide\u2010<jats:italic>co<\/jats:italic>\u2010glycolide) (PLG) nanoparticles containing an imaging probe and therapeutic gene are prepared, followed by modification with rabies virus glycoprotein (RVG) peptide for neuroblastoma\u2010targeting delivery. RVG peptide is a well\u2010known neuronal targeting ligand and is chemically conjugated to PLG nanoparticles without changing their size or shape. RVG\u2010modified nanoparticles are effective in specifically targeting neuroblastoma both in vitro and in vivo. RVG\u2010modified nanoparticles loaded with a fluorescent probe are useful to detect the tumor site in a neuroblastoma\u2010bearing mouse model, and those encapsulating a therapeutic gene cocktail (siMyc, siBcl\u20102, and siVEGF) significantly suppressed tumor growth in the mouse model. This approach to designing and tailoring of polymeric nanoparticles for targeted delivery may be useful in the development of multimodality systems for theranostic approaches.<\/jats:p>","DOI":"10.1002\/smll.201501913","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T08:26:38Z","timestamp":1447748798000},"page":"1201-1211","source":"Crossref","is-referenced-by-count":33,"title":["Optical Imaging and Gene Therapy with Neuroblastoma\u2010Targeting Polymeric Nanoparticles for Potential Theranostic Applications"],"prefix":"10.1002","volume":"12","author":[{"given":"Jangwook","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Bioengineering Hanyang University  Seoul 133\u2010791 South Korea"},{"name":"Center for Theragnosis Biomedical Research Institute Korea Institute of Science and Technology  Seoul 136\u2010791 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ju","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Hanyang University  Seoul 133\u2010791 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Theragnosis Biomedical Research Institute Korea Institute of Science and Technology  Seoul 136\u2010791 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangmeyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Theragnosis Biomedical Research Institute Korea Institute of Science and Technology  Seoul 136\u2010791 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ick Chan","family":"Kwon","sequence":"additional","affiliation":[{"name":"Center for Theragnosis Biomedical Research Institute Korea Institute of Science and Technology  Seoul 136\u2010791 South Korea"},{"name":"KU\u2010KIST School Korea University  Seoul 136\u2010701 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuen Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Hanyang University  Seoul 133\u2010791 South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,17]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.40.6.355"},{"key":"e_1_2_7_2_1","first-page":"363","volume":"61","author":"Shurin G. 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