{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:57:48Z","timestamp":1780491468249,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"44","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>The versatile Mn<jats:sub>3<\/jats:sub>[Co(CN)<jats:sub>6<\/jats:sub>]<jats:sub>2<\/jats:sub>@SiO<jats:sub>2<\/jats:sub>@Ag core\u2013shell NCs are prepared by a simple coprecipitation method. Ag nanoparticles with an average diameter of 12 nm deposited on the surface of Mn<jats:sub>3<\/jats:sub>[Co(CN)<jats:sub>6<\/jats:sub>]<jats:sub>2<\/jats:sub>@SiO<jats:sub>2<\/jats:sub> through S\u2013Ag bonding are fabricated in ethanol solution by reducing silver nitrate (AgNO<jats:sub>3<\/jats:sub>) with NaBH<jats:sub>4<\/jats:sub>. The NCs possess T<jats:sub>1<\/jats:sub>\u2013T<jats:sub>2<\/jats:sub> dual\u2010modal magnetic resonance imaging ability. The inner Prussian blue analogs (PBAs) Mn<jats:sub>3<\/jats:sub>[Co(CN)<jats:sub>6<\/jats:sub>]<jats:sub>2<\/jats:sub> exhibit bright two\u2010photon fluorescence (TPF) imaging when excited at 730 nm. Moreover, the TPF imaging intensity displays 1.85\u2010fold enhancement after loading of Ag nanoparticles. Besides, the sample also has multicolor fluorescence imaging ability under 403, 488, and 543 nm single photon excitation. The as\u2010synthesized Mn<jats:sub>3<\/jats:sub>[Co(CN)<jats:sub>6<\/jats:sub>]<jats:sub>2<\/jats:sub>@SiO<jats:sub>2<\/jats:sub>@Ag NCs show a DOX loading capacity of 600 mg g<jats:sup>\u22121<\/jats:sup> and exhibit an excellent ability of near\u2010infrared (NIR)\u2010responsive drug release and photothermal therapy (PTT) which is induced from the relative high absorbance in NIR region. The combined chemotherapy and PTT against cancer cells in vitro test shows high therapeutic efficiency. The multimodal treatment and imaging could lead to this material a potential multifunctional system for biomedical diagnosis and therapy.<\/jats:p>","DOI":"10.1002\/smll.201502102","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T15:38:52Z","timestamp":1444059532000},"page":"5956-5967","source":"Crossref","is-referenced-by-count":71,"title":["Novel Mn<sub>3<\/sub>[Co(CN)<sub>6<\/sub>]<sub>2<\/sub>@SiO<sub>2<\/sub>@Ag Core\u2013Shell Nanocube: Enhanced Two\u2010Photon Fluorescence and Magnetic Resonance Dual\u2010Modal Imaging\u2010Guided Photothermal and Chemo\u2010therapy"],"prefix":"10.1002","volume":"11","author":[{"given":"Dongdong","family":"Wang","sequence":"first","affiliation":[{"name":"Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science &amp; Engineering, CAS High Magnetic Field Laboratory University of Science and Technology of China  96 Jinzhai Road Hefei 230026 P. R. 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