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It is hypothesized that a drug delivery system that provides controlled and sustained release of PD drugs would afford better management of PD. Hollow microcapsules composed of poly\u2010<jats:sc>l<\/jats:sc>\u2010lactide (PLLA) and poly (caprolactone) (PCL) are prepared through a modified double\u2010emulsion technique. They are loaded with three PD drugs, i.e., levodopa (LD), carbidopa (CD), and entacapone (ENT), at a ratio of 4:1:8, similar to commercial PD tablets. LD and CD are localized in both the hollow cavity and PLLA\/PCL shell, while ENT is localized in the PLLA\/PCL shell. Release kinetics of hydrophobic ENT is observed to be relatively slow as compared to the other hydrophilic drugs. It is further hypothesized that encapsulating ENT into PCL as a surface coating onto these microcapsules can aid in accelerating its release. Now, these spray\u2010coated hollow microcapsules exhibit similar release kinetics, according to Higuchi's rate, for all three drugs. The results suggest that multiple drug encapsulation of LD, CD, and ENT in gastric floating microcapsules could be further developed for in vivo evaluation for the management of PD.<\/jats:p>","DOI":"10.1002\/smll.201600067","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T19:56:58Z","timestamp":1464897418000},"page":"3712-3722","source":"Crossref","is-referenced-by-count":24,"title":["Multi\u2010Drug\u2010Loaded Microcapsules with Controlled Release for Management of Parkinson's Disease"],"prefix":"10.1002","volume":"12","author":[{"given":"Jong\u2010Suep","family":"Baek","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Nanyang Technological University  50 Nanyang Avenue Singapore 639798"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee Chong","family":"Choo","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Nanyang Technological University  60 Nanyang Drive 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