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To prevent the devastating metastasis cascade from initiation, we hypothesize that a biodegradable nanomaterial loaded with the abortifacient mifepristone (MIF) and conjugated with the epithelial cell adhesion molecule antibody (aEpCAM) may serve as a safe and effective cancer metastatic preventive agent by targeting CTCs and preventing their adhesion\u2010invasion to vascular intima. It is demonstrated that MIF\u2010loaded mesoporous silica nanoparticles (MSN) coated with aEpCAM (aE\u2010MSN\u2010M) can specifically target and bind colorectal cancer cells in either cell medium or blood through EpCAM recognition proven by quantitative flow cytometric detection and free aEpCAM competitive assay. The specific binding results in downregulation of the captured cells and drives them into G0\/G1 phase primarily attributed to the effect of aEpCAM. The functional nanoparticles significantly inhibit the heteroadhesion between cancer cells and endothelial cells, suggesting the combined inhibition effects of aEpCAM and MIF on E\u2010selectin and ICAM\u20101 expression. The functionalized nanoparticles circulate in mouse blood long enough to deliver MIF and inhibit lung metastasis. The present proof\u2010of\u2010concept study shows that the aE\u2010MSN\u2010M can prevent cancer metastasis by restraining CTC activity and their adhesion\u2010invasion to vascular intima.<\/jats:p>","DOI":"10.1002\/smll.201600550","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T20:26:59Z","timestamp":1459456019000},"page":"2595-2608","source":"Crossref","is-referenced-by-count":53,"title":["The Architecture and Function of Monoclonal Antibody\u2010Functionalized Mesoporous Silica Nanoparticles Loaded with Mifepristone: Repurposing Abortifacient for Cancer Metastatic Chemoprevention"],"prefix":"10.1002","volume":"12","author":[{"given":"Yu","family":"Gao","sequence":"first","affiliation":[{"name":"Cancer Metastasis Alert and Prevention Center and Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and 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