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Although numerous methods have been developed to tailor 3D hydrogel structures, it is still challenging to fabricate complex 3D hydrogel constructs. Inspired by the capillary origami phenomenon where surface tension of a droplet on an elastic membrane can induce spontaneous folding of the membrane into 3D structures along with droplet evaporation, a facile strategy is established for the fabrication of complex 3D hydrogel constructs with programmable shapes and sizes by crosslinking hydrogels during the folding process. A mathematical model is further proposed to predict the temporal structure evolution of the folded 3D hydrogel constructs. Using this model, precise control is achieved over the 3D shapes (e.g., pyramid, pentahedron, and cube) and sizes (ranging from hundreds of micrometers to millimeters) through tuning membrane shape, dimensionless parameter of the process (elastocapillary number\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>e<\/jats:sub>\n                    ), and evaporation time. This work would be favorable to multiple areas, such as flexible electronics, tissue regeneration, and drug delivery.\n                  <\/jats:p>","DOI":"10.1002\/smll.201601147","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T08:13:50Z","timestamp":1468570430000},"page":"4492-4500","source":"Crossref","is-referenced-by-count":39,"title":["Capillary Origami Inspired Fabrication of Complex 3D Hydrogel Constructs"],"prefix":"10.1002","volume":"12","author":[{"given":"Moxiao","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace Xi'an Jiaotong University  Xi'an 710049 P. R. China"},{"name":"Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University  Xi'an 710049 P. R. 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