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In a hitherto obscure process related to aging and disease, local plugs in the lacuno\u2010canalicular network disrupt cellular communication and impede bone homeostasis. By utilizing a suite of high\u2010resolution imaging and physics\u2010based techniques, it is shown here that the local plugs develop by accumulation and fusion of calcified nanospherites in lacunae and canaliculi (micropetrosis). Two distinctive nanospherites phenotypes are found to originate from different osteocytic elements. A substantial deviation in the spherites' composition in comparison to mineralized bone further suggests a mineralization process unlike regular bone mineralization. Clearly, mineralization of osteocyte lacunae qualifies as a strong marker for degrading bone material quality in skeletal aging. The understanding of micropetrosis may guide future therapeutics toward preserving osteocyte viability to maintain mechanical competence and fracture resistance of bone in elderly individuals.<\/jats:p>","DOI":"10.1002\/smll.201602215","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T14:35:10Z","timestamp":1478529310000},"source":"Crossref","is-referenced-by-count":58,"title":["The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone"],"prefix":"10.1002","volume":"13","author":[{"given":"Petar","family":"Milovanovic","sequence":"first","affiliation":[{"name":"Institute for Osteology and Biomechanics University Medical Center Hamburg\u2010Eppendorf  Lottestrasse 55a 22529 Hamburg Germany"},{"name":"Laboratory for Anthropology Institute of Anatomy Faculty of Medicine University of Belgrade  Dr Subotica 4\/2 11000 Belgrade 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