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Developing novel high\u2010performance nanoprobes is an important basis for tumor theranostic application. Here, near\u2010infrared (NIR) fluorescent and low\u2010biotoxicity Ag<jats:sub>2<\/jats:sub>Se quantum dots (QDs) have been coupled with cetuximab, a clinical antiepidermal growth factor receptor antibody drug for tumor therapy, via a facile bioconjugation strategy to prepare multifunctional Ag<jats:sub>2<\/jats:sub>Se\u2013cetuximab nanoprobes. Compared with the Ag<jats:sub>2<\/jats:sub>Se QDs alone, the Ag<jats:sub>2<\/jats:sub>Se\u2013cetuximab nanoprobes display faster and more enrichment at the site of orthotopic tongue cancer, and thus present better NIR fluorescence contrast between the tumor and the surrounding regions. At 24 h postinjection, the NIR fluorescence of Ag<jats:sub>2<\/jats:sub>Se\u2013cetuximab nanoprobes at the tumor site is still easily detectable, whereas no fluorescence is observed for the Ag<jats:sub>2<\/jats:sub>Se QDs. Moreover, the Ag<jats:sub>2<\/jats:sub>Se\u2013cetuximab nanoprobes have also significantly inhibited the tumor growth and improved the survival rate of orthotopic tongue cancer\u2010bearing nude mice from 0% to 57.1%. Taken together, the constructed multifunctional Ag<jats:sub>2<\/jats:sub>Se\u2013cetuximab nanoprobes have achieved combined targeted imaging and therapy of orthotopic tongue cancer, which may greatly contribute to the development of nanotheranostics.<\/jats:p>","DOI":"10.1002\/smll.201602309","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T14:37:05Z","timestamp":1478529425000},"source":"Crossref","is-referenced-by-count":71,"title":["Near\u2010Infrared Fluorescent Ag<sub>2<\/sub>Se\u2013Cetuximab Nanoprobes for Targeted Imaging and Therapy of Cancer"],"prefix":"10.1002","volume":"13","author":[{"given":"Chun\u2010Nan","family":"Zhu","sequence":"first","affiliation":[{"name":"Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education) College of Chemistry and Molecular Sciences State Key Laboratory of Virology The Institute for Advanced Studies and Wuhan Institute of Biotechnology Wuhan University  Wuhan 430072 P. R. 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