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In this study, a new class of polymeric photothermal agents based on poly(<jats:italic>N<\/jats:italic>\u2010phenylglycine) (PNPG) suitable for use in near\u2010infrared (NIR) phototherapy of malignant melanoma is designed and developed. PNPG is obtained via polymerization of <jats:italic>N<\/jats:italic>\u2010phenylglycine (NPG). Carboxylate functionality of NPG allows building multifunctional systems using covalent bonding. This approach avoids complicated issues typically associated with preparation of polymeric photothermal agents. Moreover, PNPG skeleton exhibits pH\u2010responsive NIR absorption and an ability to generate reactive oxygen species, which makes its derivatives attractive photothermal therapy (PTT)\/photodynamic therapy (PDT) dual\u2010modal agents with pH\u2010responsive features. PNPG is modified using hyaluronic acid (HA) and polyethylene glycol diamine (PEG\u2010diamine) acting as the coupling agent. The resultant HA\u2010modified PNPG (PNPG\u2010PEG\u2010HA) shows negligible cytotoxicity and effectively targets CD44\u2010overexpressing cancer cells. Furthermore, the results of in vitro and in vivo experiments reveal that PNPG\u2010PEG\u2010HA selectively kills B16 cells and suppresses malignant melanoma tumor growth upon exposure to NIR light (808 nm), indicating that PNPG\u2010PEG\u2010HA can serve as a very promising nanoplatform for targeted dual\u2010modality PTT\/PDT of melanoma.<\/jats:p>","DOI":"10.1002\/smll.201602496","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T15:54:03Z","timestamp":1481990043000},"source":"Crossref","is-referenced-by-count":97,"title":["Poly(<i>N<\/i>\u2010phenylglycine)\u2010Based Nanoparticles as Highly Effective and Targeted Near\u2010Infrared Photothermal Therapy\/Photodynamic Therapeutic Agents for Malignant Melanoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Bang\u2010Ping","family":"Jiang","sequence":"first","affiliation":[{"name":"School of Chemistry and Pharmaceutical Science Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal University  Guilin 541004 P. 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