{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:33:18Z","timestamp":1777638798929,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:00:00Z","timestamp":1480896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2014R1A2A2A09053061"],"award-info":[{"award-number":["2014R1A2A2A09053061"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>A novel droplet\u2010based surface\u2010enhanced Raman scattering (SERS) sensor for high\u2010throughput real\u2010time SERS monitoring is presented. The developed sensors are based on a droplet\u2010guiding\u2010track\u2010engraved superhydrophobic substrate covered with hierarchical SERS\u2010active Ag dendrites. The droplet\u2010guiding track with a droplet stopper is designed to manipulate the movement of a droplet on the superhydrophobic substrate. The superhydrophobic Ag dendritic substrates are fabricated through a galvanic displacement reaction and subsequent self\u2010assembled monolayer coating. The optimal galvanic reaction time to fabricate a SERS\u2010active Ag dendritic substrate for effective SERS detection is determined, with the optimized substrate exhibiting an enhancement factor of 6.3 \u00d7 10<jats:sup>5<\/jats:sup>. The height of the droplet stopper is optimized to control droplet motion, including moving and stopping. Based on the manipulation of individual droplets, the optimized droplet\u2010based real\u2010time SERS sensor shows high resistance to surface contaminants, and droplets containing rhodamine 6G, Nile blue A, and malachite green are successively controlled and detected without spectral interference. This noble droplet\u2010based SERS sensor reduces sample preparation time to a few seconds and increased detection rate to 0.5 <jats:italic>\u00b5<\/jats:italic>L s<jats:sup>\u22121<\/jats:sup> through the simple operation mechanism of the sensor. Accordingly, our sensor enables high\u2010throughput real\u2010time molecular detection of various target analytes for real\u2010time chemical and biological monitoring.<\/jats:p>","DOI":"10.1002\/smll.201602865","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T13:42:51Z","timestamp":1480945371000},"source":"Crossref","is-referenced-by-count":48,"title":["A Droplet\u2010Based High\u2010Throughput SERS Platform on a Droplet\u2010Guiding\u2010Track\u2010Engraved Superhydrophobic Substrate"],"prefix":"10.1002","volume":"13","author":[{"given":"Sera","family":"Shin","sequence":"first","affiliation":[{"name":"School of Electrical and Electronic Engineering Yonsei University  50 Yonsei\u2010ro Seodaemun\u2010Gu Seoul 03722 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaehong","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Electrical and Electronic Engineering Yonsei University  50 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