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Recently, scientists have subverted these nature functions and used ferritin cage structures of nanometer dimensions for encapsulation of guest molecules such as anti\u2010cancer drugs or bioactive nutrients based on pH induced ferritin disassembly and reassembly property. However, prior to this study, ferritin nanocage was required to disassemble only under harsh pH conditions (\u22642.0 or \u226511.0), followed by reassembly at near neutral pH. Such harsh conditions can cause protein or guest molecules damage to a great extent during this pH\u2010induced unfolding\u2013refolding process. Here, we provide evidence demonstrating that the apoferritin shell is flexible rather than rigid. Indeed, we found that two large complex molecules, uranyl acetate dihydrate and phosphotungstic acid, can reach the cavity of both plant and animal apoferritin followed by mineralization. Moreover, large organic compound such as curcumin and doxorubicin can also be encapsulated within ferritin cavity by its mixing with protein. This strategy will increase the use of ferritin in nanotechnology, and could be also applicable to other shell\u2010like proteins as templates to prepare nanomaterials.<\/jats:p>","DOI":"10.1002\/smll.201701045","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T11:52:36Z","timestamp":1502193156000},"source":"Crossref","is-referenced-by-count":55,"title":["The Size Flexibility of Ferritin Nanocage Opens a New Way to Prepare Nanomaterials"],"prefix":"10.1002","volume":"13","author":[{"given":"Shengli","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science and Nutritional Engineering Beijing Key Laboratory of Functional Food from Plant Resources China Agricultural University  Beijing 100083 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Zang","sequence":"additional","affiliation":[{"name":"Beijing Advanced 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